126 MICRO-ORGANISMS AND DISEASE. [CHAP. 



Quite recently Marchiafava and Celli 1 found that the red 

 blood discs of patients affected with recent malaria contain 

 peculiar homogeneous bodies, possessed of amoeboid move- 

 ment, in size a fraction of that of the blood discs. They call 

 them hcemoplasmodium malaria. Sometimes these plasmodia 

 include pigment granules assimilated from the pigment of 

 the blood discs. Such pigmented plasmodia had been 

 already noticed by Laveran. Marchiafava and Celli found 

 that malaria blood containing the plasmodia is capable of 

 producing intermittent fever in man after intravenous in- 

 jection. The blood corpuscles of a person so infected again 

 contain the haemoplasmodia. 



(/) Bacillus of ulcerative stomatitis in the calf. In the 

 Lancet of May, 1883, A. Lingard and E. Batt described 

 peculiar bacilli in ulcerations occurring on the tongue and 

 buccal mucous membrane of the calf. " The typical ulcer 

 in advanced cases consists of a sore with free overhanging 

 edges. On section through the sore the tongue is found 

 necrosed to a considerable depth." " Whenever the sore 

 touches any other part of the mouth or cheek, the disease is 

 communicated and rapidly spreads. In some cases similar 

 necrotic changes had taken place in the lung. The line of 

 junction of the necrotic with the healthy tissues was found 

 to be occupied by a dense mass of bacilli having the appear- 

 ance of a dense phalanx advancing upon the healthy tissues. 

 The disease has been proved capable of transmission (to the 

 rabbit and mouse) by injection of the bacilli in question, 

 which are equally numerous and virulent after passing 

 through several generations by inoculation." 



The disease often ends fatally in calves. 



The best method of staining the bacilli was found to be 

 1 Fortschritte d. Med.^QS. xi., xviii., xxiv., 1885. 



