140 MICRO-ORGANISMS AND DISEASE. [CHAP. 



indistinct, and in some the cell-substance was seen to break 

 down, whereby the bacilli became free. In these respects, 

 in the size, distribution, and character of the bacilli, there 

 exists a remarkable similarity between the nodules in leprosy 

 and the nodules just mentioned. 



FIG. 75. Two CELLS OF THE LEPROSY (?) NODULES IN THE LIVER OF A 

 BIRD (RHEA). 



The cell-substance is crowded with minute bacilli, similar to leprosy-bacilli 

 Magnifying power 700. (Stained with magenta.) 



(f) Bacillus of malignant oedema (Koch), vibrion septiqiie 

 (Pasteur). By inoculating mice, rabbits, and especially 

 guinea-pigs subcutaneously with a comparatively large 

 quantity of earth, or of putrid fluid, one occasionally 

 produces death in twenty-four to forty-eight hours. This 

 form of septicaemia is also called " Pasteur's septicaemia," 

 and is of course distinct and different from Davaine's 

 septicaemia. 1 At the seat of the inoculation and spreading 

 from it into the subcutaneous tissue of adjoining parts there 

 is much discoloration and occasionally haemorrhage ; a 

 turbid offensively-smelling ichor fills the spaces of the 

 subcutaneous tissue, and in it are found large numbers cf 

 bacilli, some motile, others not. The lungs are hyperaemic 



1 Rosenberger maintains ( Centralblatt f. d. med. Wiss. 4, 1883) thnt 

 the blood and exudation-fluids of rabbits dead of Davaine's or Pasteur's 

 septicaemia can be effectually sterilised by heat without losing their 

 specific action, reproducing on injection into fresh animals the disease 

 with the recurrence of the organisms characteristic of the disease. 

 Dowdeswell, however, states (Proceedings of the Royal Society, 221, 

 1882) that this is not the case, for on really effectual sterilisation by 

 heat the organisms are killed, and the fluids become innocuous. 



