206 MICRO-ORGANISMS AND DISEASE. [CH. xvi. 



disease in man characterised by metastatic abscesses 

 (spreading it seems from a primary abscess of the jaw) in 

 various internal organs, due to the presence of a fungus, 

 which afterwards was identified as actinomyces, and Ponfick l 

 has clearly established that in man it is not a rare disease. 



According to careful observations, Johne 2 succeeded in 

 transmitting the disease from cattle to cattle by inoculation, 

 but not by feeding. He also found 3 in twenty out of twenty- 

 one healthy pigs examined, the actinomyces present in the 

 crypts of the tonsils. 



Israel 4 succeeded in transmitting the disease to a rabbit 

 by inserting into the peritoneal cavity a piece of a human 

 antinomyces-ttimour. 



R. Virchow quite recently, 5 in conjunction with O. Israel 

 and Duncker, ascertained that pork occasionally contained 

 whitish chalky nodules, larger than those due to trichinae, 

 and containing in their interior the actinomyces. 



O. Israel 6 claims to have succeeded in artificially cul- 

 tivating the actinomyces on solid ox-serum ; in fluid media 

 the growth does not succeed, owing to the swelling up and 

 death of the actinomyces-corpuscles. 



1 Die Actinomykose des Menschen, Berlin, 1881. 



2 Deutsche Zeitschr. f. Thiermedidn, vii. 1881. 



3 Centralbl.f. med. Wiss. 15, 1 88 1. 



4 Ibid, xxvii. 1883. 



5 Virchovtfs Archiv, vol. xcv. p. 544. 



6 Ibid. vol. xcv. p. 142. 



