I/O 



THE TISSUES. 



Dogiel, and the account here given follows closely his descrip- 

 tion. 



End-bulbs of Krause. Under this designation there are described 

 a variety of endings which vary slightly in size and shape. They 

 are found in the conjunctiva and edge of the cornea, in the lips and 

 lining of the oral cavity, in the glans penis and clitoris, and prob- 

 ably also in other parts of the dermis. In form they are round, 

 oval, or pear-shaped. Their size varies from 0.02 to 0.03 mm. 

 long and from 0.015 to 0.025 mm. broad for the smaller ones, 

 and from 0.045 to o. 10 mm. long and from 0.02 to 0.08 mm. 

 broad for the larger ones. They have a relatively thin capsule 

 in which nuclei are quite numerous. One, two, or three medul- 

 lated nerves go to each end-bulb. These may lose their medul- 

 lary sheath at the capsule or at a variable distance from it. The 

 naked axis-cylinders, soon after entering the capsule, divide into two, 

 three, or four branches, which form several circular or spiral turns 

 in the same or in opposite directions. These fibers then divide into 

 varicose branches, which undergo further division, the resulting 

 branches interlacing to form a bundle of variously tangled fibers 

 which may be loosely or tightly woven. 



Between the nerve-fibers and their branches, within the capsule, 



there is found a semifluid sub- 

 stance, which is granular in fixed 

 preparations. 



Meissner 's Corpuscles. These 

 corpuscles are found in man in 

 the subepidermal connective tissue 

 of the hand and foot and outer 

 surface of the forearm, in the nip- 

 ple, border of the eyelids, lips, 

 glans penis and clitoris. They are 

 most numerous in the palmar sur- 

 face of the distal phalanx of the 

 fingers. They are oval in shape, 

 sometimes somewhat irregular, 

 and vary in size, being from 45 // 

 to 50 n broad and from 1 10 // to 

 1 80 // long. They possess a thin 

 connective-tissue capsule, in which 

 are found round or oval nuclei, 

 some of which have an oblique 

 position to the axis of the corpus- 

 cle. One medullated nerve ends 

 in the smaller corpuscles, two or 

 three or even more in the larger 

 ones. After piercing the capsule, 

 the medullated nerves lose their 

 medullary sheaths, the naked axis-cylinders making a variable 



Fig. 137. Meissner's tactile corpus- 

 cle ; methylene-blue stain (Dogiel, " In- 

 ternal. Monatsschr. f. Anat. u. Phys.," 

 vol. IX). 



