ELEMENTARY COMPOSITION OF OXYHAMOGLOBIN. 199 



The subsequent researches of Hoppe-Seyler soon demonstrated, 

 however, that the blood crystals obtained from the blood of different 

 animals did not possess an identical composition, though the differences 

 brought out by Hoppe-Seyler's analyses were not very great. His 

 results are shown in the table on p. 198. 1 



The very numerous analyses of oxyhaemoglobin of different animals, 

 made in recent years by Kossel, 2 Otto, 3 Zinoffsky, 4 Hiifner, 5 Jaquet, 6 

 and others exhibit, however, such extraordinary discrepancies in the 

 results of ultimate organic analysis as to preclude a precise answer 

 being given to such simple questions as the following : 



Is haemoglobin a body, having a constant composition in animals 

 of the same species ? 



Does the haemoglobin of different animals vary in chemical com- 

 position, and if so, within what limits ? 



Results of the more recent Analyses of Oxyhcemoglolin (1878-1890). 



1 Med. Chem. Vntersuch., Berlin, 1868, Heft 3, S. 370. 



2 The results of the analyses made by Dr. Kossel were published in a paper by Hoppe- 

 Seyler, entitled "Weitere Mittheilungen ueber die Eigenschaften des Blutfarbstotfs Das 

 Oxyhamoglobin des Pferdeblutes, " Ztschr. /. physiol. Chem., Strassburg, 1878-79, Bd. ii. 

 S. 149-155. 



a "Ueber das Oxyhamoglobin des Schweines," ibid., 1882-83, Bd. vii. S. 57-68. 



4 "Ueber die Grbsse des Hamoglobinmoleculs," ibid., 1886, Bd. x. S. 16-34. 



5 "Ueber das Oxyhamoglobin des Pferdes," Ztschr. f. physiol. Chem., Strassburg, 

 1883-84, Bd. viii. S. 358-365; "Beitrage zur Lehre voni Blutfarbstoffe," in Beitr. s. 

 Physiol. O. Ludwifj 2. s. Geburtst. etc., Leipzig, 18,87, S. 74-81; "Neue Yersuche zur 

 Bestimmung des SauerstofFscapacitat des Blutfarbstoffs," Arch. f. Physiol., Leipzig, 1894, 

 S. 130-176. See especially S. 174-176. 



6 " Elementaranalyse des Hundeblut-Hamoglobins," Ztschr. f. physiol. Chem., Strass- 

 burg, 1888, Bd. xii. S. 285-288 ; Beitrage zur Kenntniss des Blutfarbstoffes," ibid., 

 1890, Bd. xiv. S. 289-296. 



7 This analysis, which is adduced for purposes of comparison, does not fall within the 

 dates given above, having been published in 1868. 



8 Ztschr. f. physiol. Chem., Strassburg, 1888, Bd. xii. S. 285. 



9 Ibid., 1890, Bd. xiv. S. 289. 



10 Ibid., 187S-79, Bd. ii. S. 149. Refer to Note 2. 



11 Arch. f. d. ges. Physiol., Bonn, 1884, Bd. xxxi. S. 240. 



12 Hiifner, Ztschr. f. physiol. Chem., Strassburg, 1883-84, Bd. viii. S. 358. This paper 

 contains the results of Biicheler's researches, which have been carried out under Hiifner's 

 direction, and had appeared as a Tubingen Dissertation in 1883. 



13 Ibid., Strassburg, 1886, Bd. x. S. 16. 



14 Beitr. z. Physiol. C. Ludwig z. s. Geburtst. etc., Leipzig, 1887, S. 74. 



15 Arch. f. Physiol., Leipzig, 1894, S. 174. 



10 Ztschr. f. physiol. Chem., Strassburg, 1882-83, Bd. vii. S. 57. 



17 Beitr. z. Physiol. C. Ludwig z. s. Geburtst. etc., Leipzig, 1887, S. 74. 



18 Ztschr. f. physiol. Chem., Strassburg, Bd. xiv. S. 289. 



