568 



MECHANISM OF BILE SECRETION. 



Among these substances are the salts of the bile acids, and all in- 

 vestigators find that the administration of these causes an enormous 

 increase in bile secretion. But while such pure haemolytics as toluy- 

 lenediamin and arseniuretted hydrogen cause only a transitory increase 

 in the secretion, and produce a very concentrated, bile, the bile salts not 

 only markedly increase the solids, but also the water secreted. The 

 following record of one of Eosenberg's 1 experiments shows this effect : 



Again, Stadelman's work shows that, while the ordinary hsemolytics 

 do not increase the secretion of bile salts, the administration of the 

 bile salts leads to a marked increase in their percentage amount in the 

 bile. Paschkis' experiments 2 indicate that, while glycine and taurine 

 have little action as cholagogues, cholalic acid is exceedingly active. It 

 would thus seem that these substances act not only in virtue of their 

 hsemolytic action, but by reason of a special stimulating influence upon 

 the liver cells. 



Salicylate of soda, which also has a hsemolytic action, greatly 

 increases the flow of bile. But while the bile salts cause an increase 

 in the solids, this substance produces a very marked dilution of the 

 bile (Rutherford, 8 Lewaschew, 4 and Eosenberg 5 ). 



One of Eosenberg's experiments is here given to show this effect. 



1 Loc. cit. 2 Loc. cit. 



3 "Action of Drugs on the Secretion of Bile," Edinburgh, 1880, p. 118. 



4 Ztschr.f. klin. Med., Berlin, 1884, Bd. viii. S. 67. 



5 Arch.f. d. ges. PhysioL, Bonn, 1890, Bd. xlvi. S. 355. 



