944 INFLUENCE OF DUCTLESS GLANDS ON METABOLISM. 



an increased production of heat. This increase of carbonic acid does not 

 take place immediately, but only conies on after a certain period of 

 time ; the temperature of the body being in the meanwhile maintained 

 normal by those physical changes which occur in the circulation, and 

 which allow the quantity of blood brought to the skin, and the amount 

 of heat thereby lost from the general surface of the body, to be varied. 

 Now, it is precisely these vasomotor changes which appear to be lack- 

 ing after removal of the thyroid ; for the production of carbon dioxide 

 becomes almost immediately increased by exposing thyroid ectomised 

 animals to a low temperature. Cardiac palpitations with increased 



M/\A 





FIG. 85. Effect in the dog upon the blood pressure of the intravenous injection of decoc- 

 tion of thyroid. Time in seconds. The line above the time tracing is the abscissa 

 of the mercurial manometer. 



pulse frequency, often accompanied by a feeling of giddiness, may 

 sometimes be produced by large doses of fresh thyroid; after a time 

 glycosuria and increase of urea appear. 1 Experiments upon the effect 

 of thyroid feeding on metabolism have been made by various observers. 2 

 Eichter 3 found in man no marked effect on nitrogenous metabolism, 

 but Bleibtreu and Wendelstadt and also Roos got a distinct increase 

 of excreted nitrogen during thyroid feeding. Schondorff obtained an 

 increased excretion of nitrogen during the first eight days (in dog) ; 

 after that, N-balance was maintained, while the body-fat was greatly 

 diminished in amount. The sodium chloride and phosphoric acid were 

 also somewhat increased. Bettmann 4 states that thyroid feeding tends 

 to produce "alimentary glycosuria" (see p. 881). 



1 Georgiewsky, Centralbl. f. d. med. Wissensch., Berlin, 1895, Bd. xxvii. 



2 Napier, Lancet, London, 1 893, vol. ii. p. 805 ; Vermehren, Deutsche med. Wchnschr. , Leipzig, 

 1893, No. 11 ; Dening, Munchen. med. Wchnschr., 1895, S. 464 ; Bleibtreu and Wendelstadt, 

 Deutsche med. Wchnschr., Leipzig, 1895, S. 346; Mediger, Diss., Greifswald, 1895 

 (abstract in Centralbl. f. Nervenh. u. Psychiat., Coblenz u. Leipzig, Bd. xviii. S. 289) ; 

 Lanz, Deutsche med. Wchnschr., Leipzig, 1895, S. 597 ; Irsal, Vas. and Gara, ibid., 1896, 

 Bd. xxii. S. 439; Schondorff, Arch. f. d. ges. PhysioL, Bonn, 1896, Bd'. Ixiii. S. 423; 

 Gluziriski and Lemberger, Centralbl. f. innereMed., Leipzig, Bd. xviii. S. 90 ; Roos, Ztschr. 

 f. physiol. Chem., Strassburg, 1895, 'Bd. xxi. S. 19 ; and 1896, Bd. xxii. S. 18; Giirber, 



Sitzungsb. d. phys.-med. Gesellsch. zu Wiirzburg, 1896, S. 101. 



3 CentralU.f. innere Med., Leipzig, 1896, S. 65. 



4 Berl. Uin. Wchnschr., 1897, S. 518. 



