tion, due to it alone; it is hardly ever 

 applied in combination with synergists 

 which might obscure the activity of in- 

 dividual ingredients. 



This remarkable therapeutic activity 

 of iodine is such that, when properly 

 applied in some of its forms, its pres- 

 ence can be demonstrated in the under- 

 lying tissues. After prolonged courses 

 of topical application, its action is oc- 

 casionally appreciated, both subjectively 

 and objectively, in the evidence of more 

 or less clearly defined constitutional or 

 systemic indications of its presence 

 within the animal organism. 



From this, it is apparent that, in io- 

 dine preparations of a particular class, 

 we have an agent whose topical reme- 

 dial effects are, in some slight measure, 

 due to systemic action ; in part at least, 

 this action being the effect of great 

 physiological activity exdrted in the 

 limited area of its topical application. 

 13 



