298 



THE TUBERCLE BACILLUS 



If the animal be killed within a fortnight to three weeks after inoculation the 

 lesions, especially the tubercles on the spleen and liver, will be found to have 

 attained their characteristic appearances. At this period of the disease the 



Cervical lymphatic glands 



Post-sternal 

 lymphatic glands' 



Post-manubrial 

 lymphatic gland 



Axillary 

 lymphatic glands 



Inguinal 



lymphatic glands "~ - 



Axillary 

 lymphatic gU n 



, - Mesenteric gl; n 



Inguinal 

 ~" lymphatic gla 



FIG. 189. Tuberculous guinea-pig (sub-cutaneous inoculation) (3J weeks). 



The areas marked black show the structures mainly affected, viz. the inguinal, 

 axillary, post-manubrial, post-sternal and cervical lymphatic glands and the 

 spleen. 





lesions are most marked in the glands on the same side as and adjacent to 

 the site of inoculation. It is only towards the second month that tubercles 

 appear in the bronchial glands and lungs. 



These appearances were first described by Villemin hence this type of 

 generalization of the disease is sometimes known as the Villemin type. 



[The course of the disease in guinea-pigs following the sub-cutaneous inocula- 

 tion of bovine tubercle bacilli was worked out by A. S. and F. Griffith. The 



