512 THE BACILLUS OF WHOOPING COUGH 



c. The bacillus of Bordet and Gengou, when inoculated into the peritoneal cavity 

 of a guinea-pig, causes the death of the animal from toxaemia : the endotoxin of the 

 bacillus sets up necrosis. Klimenko failed to reproduce whooping cough in guinea- 

 pigs and most laboratory animals : but in young dogs and in monkeys (Cynocephalus, 

 Macacus, Cercopithecus) a disease characterized by fever, catarrh of the nasal and 

 ocular mucous membranes, sneezing, and accompanied by a hoarse cough, without 

 spasms but occasionally causing vomiting, followed infection by the bacillus whether 

 produced by inoculation into the naso-pharyngeal cavities or by contagion. Young 

 dogs often died of pneumonia after about 5 or 6 weeks and the bacillus was found in 

 the laryngeal secretion and in the pulmonary foci. 



