NEUTRALISATION OF SIMPLE POISONS 



211 



NEUTRALISATION OF i c.c. OF LYSIN FROM ANCISTRODON PISCIVORUS, 

 ACTING ON AN EMULSION OF 5 PER CENT DOG BLOOD 



Here the deviation from the calculated figures is still 

 greater than in the two preceding cases. K is about 

 0.006, or a little larger than for the diphtheria-poison, 

 which exhibits the least value of K(K= 0.004). From 

 these experiments it follows that the assertion of Kyes 

 and Sachs, that the neutralisation curve for cobralysin is 

 quite rectilinear (corresponding to l=o), is not exact. 

 This assertion does not even agree with the experiments 

 of Kyes himself. The conclusions which these authors 

 have drawn from their not entirely strict observations 

 can be no longer maintained. Even had the curve been 

 quite rectilinear, that would not have allowed them to 

 conclude that a deviation from the straight line indicates 

 the presence of toxoids and toxons (cf. behaviour of am- 

 monia). It is also noteworthy that Kyes has made no 

 experiments with mixtures containing an excess of antily- 

 sin, or at least he has not mentioned them. 



