NEUTRALISATION OF SIMPLE POISONS 2I/ 



2, 3, and 1.8 and reaches at the end the value 1.3. 

 For the diphtheria-poison No. 471 (September, 1903), the 

 corresponding values are 150, n, 7.3 and 4.3. For the 

 neutralisation of tetanolysin with cholesterin, / sinks 

 from an infinite value through 11.5 to 5.1. For the neu- 

 tralisation of saponin,/ goes through a minimum. With 

 cholesterin it gives for /-values, 6.5, 3.1, and 5 ; with ox- 

 serum the values 5, 1.2, 2.8, and 4.1. There can therefore 

 be no possibility that / may be regarded as a constant, 

 and therefore the hypothesis of Biltz must be regarded as 

 untenable. 



On the other hand, we may sum it up as our experience, 

 that we are entitled to regard the formula of Guldberg 

 and Waage, 

 (Cone, of toxin) x (cone, of antitoxin) 



= K (cone, of reaction-products)* 7 , 



where /= 2 or 1.5, or sometimes i, as valid in all the ex- 

 amined cases of neutralisation of poisons by antitoxins. 



