160 



ANAPHYLAXIS IN ITS RELATION TO DISEASE 



I/ 



usually from eight to twelve days we now find that symptoms 

 appear after from four to seven days. Reactions of this order 



Days I 



Horse 



Serum 



(Allergen) 



FIG. 2 

 15 



First Injection 



.22 



29 



Period of Serum 



Incubation Sickness 



Second Injection of 

 Horse Serum 



rgin 



Immediate 

 Reaction 



Diagram representing the interaction between horse serum and the corresponding ergin in 

 relation to the development of serum sickness and the occurrence of an immediate reaction. 

 (Taken from v. Pirquet.) 



FIG. 3 



Allergen 



(Second 



injection) 



Days 1 8 



Brief Seru 

 incubation Sickness 

 period 



Diagram representing the interaction be- 

 tween horse serum and the corresponding ergin 

 in relation to the occurrence of a double reac- 

 tion, i. e., an immediate followed by a hastened 

 reaction. (Taken from v. Pirquet.) 



Immediate Hastened 

 Reaction Reaction 



Diagram representing the interaction be- 

 tween horse serum and the corresponding 

 ergin in relation to the occurrence of a hastened 

 reaction. Note the greater depth of the 

 antibody fraction as compared with the 

 preceding figure. (Taken from v. Pirquet.) 



v. Pirquet speaks of as hastened reactions. They are readily accounted 

 for if we remember that a cell which has once been stimulated to 

 active antibody formation (sc., liberation) will subsequently respond 



