PLAGUE 241 



taneous injections, and one of 50 per cent, when used intravenously; 

 while the general death-rate among the non-injected cases was 63.4 

 per cent. Other observers contrast a mortality of 57.5 per cent, 

 among the treated with one of 84.3 per cent, among the untreated 

 cases. The verdict among those who have had experience with the 

 serum seems to have been that the serum treatment produced a 

 favorable rather than an unfavorable impression, which, after all, 

 is scanty praise. 



Jegunoff administered the serum intravenously, together with 

 physiological salt solution, giving 140 c.c. of serum with 500 to 

 700 c.c. of saline to start with, and a second injection of 80 to 

 120 c.c. of serum within seven and one-half to twenty-three hours 

 after the first. 



TYPHOID FEVER 



While antisera against typhoid fever have been proposed by a 

 number of different observers, their value seems to be so problem- 

 atical that their discussion may very well be omitted at this place. 



PLAGUE 



Against plague also antisera have been produced, which seem to 

 be essentially of bactericidal nature (Yersin), though the preparation 

 of Lustig may have feeble antitoxic properties. Both the serum of 

 Lustig and that of Yersin have been tried out by the Plague Com- 

 mission of India, but the reports are not very encouraging. Whether 

 its use in combination with vaccination might not prove of greater 

 value than vaccination alone, and especially in persons who have 

 been actually exposed to the infection, future investigations will 

 have to decide, but w^ould, a priori, seem likely. 



BACTERIOLYTIC-BACTERIOTROPIC IMMUNIZATION. 



Among the bacteriolytic-bacteriotropic immune sera which find 

 employment in the treatment of maladies to which the human being 

 is subject, the most important are those which are directed against 

 16 



