CONTENTS 7 



PAQJD 



CHAPTER XXV. CYTOTOXINS 534 



Nomenclature, 534 Nature and general properties of cytotoxins, 534 

 Preparation of cytotoxins, 535 Methods of studying cytotoxins, 535 Specific- - 

 ity of cytotoxins, 536 Autocytotoxins, 537 Isocytotoxins, 538 Anticytotoxic 

 serums, 538 Kinds of cytotoxins, 538 Spermatotoxin, 538 Epitheliotoxin, 

 538 Leukotoxin, 538 Nephrotoxin, 538 Hepatotoxin, 539 Gastrotoxin, 

 539 Syncytotoxin, 539 Neurotoxin, 540 Thyrotoxin, 540 Role of cyto- 

 toxins in immunity, 540 Practical applications, 540 Cytotoxic cancer reac- 

 tion, 541. 



CHAPTER XXVI. THE RELATION OF COLLOIDS AND LIPOIDS TO IMMUNITY . . . 543 



Kinds of colloids, 543 Nature and properties of colloids, 543 Analogy be- 

 tween the reactions of immunity and those of colloidal chemistry, 548 Anti- 

 toxins, 548 Agglutinins and precipitins, 55fr Hemolysins, 551 Complement 

 fixation as a colloid reaction, 552 The relation of lipoids to immunity, 553 

 Lange's colloidal gold reaction, 555 The epiphanin reaction, 559 The miostag- 

 min reaction, 563. 



CHAPTER XXVII. ANAPHYLAXIS 567 



Historic, 568 Definition, 571 Phenomena of anaphylaxis, 572 Mechan- 

 ism of anaphylaxis, 577 Anaphylactogens or allergens, 579 The humeral or 

 anaphylotoxin theories of anaphylaxis, 584 Anaphylactin (allergin), 588 

 Theories of anaphylaxis, 591 Cellular theory of anaphylaxis, 594^ Passive 

 anaphylaxis, 596 Anti-anaphylaxis or desensitization, 599 Specificity of 

 anaphylaxis, 601. 



PART IV 



APPLIED IMMUNITY IN THE PROPHYLAXIS, DIAGNOSIS, AND 

 TREATMENT OF DISEASE SPECIFIC THERAPY 



CHAPTER XXVIII. ANAPHYLAXIS IN ITS RELATION TO INFECTION AND IM- 

 MUNITY. ANAPHYLACTIC OR ALLERGIC REACTIONS 602 



Relation of anaphylaxis to infectious diseases, 603 Relation of anaphylaxis 

 to non-infectious diseases, 608 Serum disease, 608 Idiosyncrasies, 614 

 Relation of anaphylaxis to immunity, 618 Anaphylactic or allergic skin reac- 

 tions, 620 Subcutaneous tuberculin reaction, 633 Intracutaneous tuberculin 

 reaction, 636 Cutaneous tuberculin reaction, 637 Conjunctival tuberculin re- 

 action, 639 Percutaneous tuberculin reaction, 640 Tuberculin reactions 

 among the lower animals, 641 The luetin reaction, 642 The mallein reaction, 

 647 Abortin reaction, 648 Allergic reactions in typhoid fever, 649 Allergic 

 reactions in other diseases, 652. 



CHAPTER XXIX. ACTIVE IMMUNIZATION. VACCINES IN THE PROPHYLAXIS 



AND TREATMENT OF DISEASE. VACCINE THERAPY 654 



Historic, 654 Nomenclature, 656 Method of preparing vaccines, 657 

 Mechanism of active immunization, 659 Non-specific activity, 663 Living 

 versus dead vaccines, 664 Sensitized vaccines, 665 Autogenous versus stock 

 bacterial vaccines, 665 The negative phase, 666 Contraindications to active 

 immunization, 667. Prophylactic Immunization or Vaccination, 668 In small- 

 pox, 668 In rabies, 681 In typhoid fever, 688 In paratyphoid fever, 693 

 In typhus fever, 694 In pneumonia, 694 In plague, 694 In cholera, 697 In 

 dysentery, 699 In cerebrospinal meningitis, 699 In scarlet fever, 699 In 

 pertussis, 700 In anthrax, 700 In black-leg, 702. Therapeutic Immunization, 

 Bacterial Vaccine Therapy, 702 Principles, 702 Jnfected wounds, 703 Focal 

 infections, 704 Diseases of the skin, 704 Diseases of the genito-urinary sys- 

 tem, 706 Diseases of the respiratory system, 708 Acute general infections, 

 713 Tuberculin therapy, 713. 



