326 BACTERIOLOG Y. 



Of 990 persons inoculated twice, 6 contracted plague, 

 of which 1, or 0.1+ per cent, of those inoculated, died. 



Of 270 persons inoculated once, 5 contracted plague, 

 and 1, or 0.3+ per cent, of those inoculated, died. 



Of 760 persons not inoculated, 35 contracted plague, 

 and 21, or 2.7+ per cent, of those not inoculated, died. 



These results indicate a reduction in the mortality of 

 94.1 per cent, in those who had been inoculated. 



In Hubli there were, in the summer of 1898, 24,631 

 inoculated, compared with 17,786 uninoculated persons. 

 In that city the mortality from plague for the inoculated 

 was 89.6 per cent, lower than for the uninoculated, and 

 Bannerman states that in practically all instances a 

 reduction in mortality of about 90 per cent, is brought 

 about by the anti-plague vaccination. 



Forsyth l reports on 30,609 cases in India that had 

 been vaccinated by the Haffkine method, of which 

 number 329 were subsequently attacked by plague, 50 

 of whom died, a case mortality of 15.1 per cent. He 

 gives a table showing the relative behavior of uninocu- 

 lated and inoculated persons toward plague. 



No in OasMof Attack- Death- Case mor- 



Classes. ^J" iSe rate P 6 * ***. rate per tality per 



(a) Uninoculated, 31,874 1457 4.5 659 2.06 4-V2 

 (6) Inoculated, 12,886 171 1.3 29 0.22 16.9 



The anti-plague vaccine is administered in doses of 

 5 c.c. The reaction following the inoculation differs in 

 different individuals, especially with regard to the tem- 

 ]K-rature. Haffkine recommends for immunizing pur- 

 poses the employment of smaller doses for the first 

 injection, and after the subsidence of the reaction the 

 use of a larger second injection. Even under these 

 conditions the reactions are sometimes quite marked. 



1 Forsyth : The Lancet, vol. ii., 1903, p. 1646. 



