598 BACTERIOLOGY. 



in the second it is already prepared, and is introduced 

 as such into the second animal. 



These authors found the serum of artificially immun- 

 ized animals to be not only capable of rendering other 

 animals immune, but to be possessed of curative powers 

 when the disease was already in progress. The serum 

 of immunized animals when injected into the circula- 

 tion of animals in which there was a body-temperature 

 of from 40.4 to 41 C. reduced this temperature to 

 normal (37.5 C.) in twelve consecutive experiments 

 during the first twenty-four hours following its employ- 

 ment. 



In their opinion, the crisis seen in pneumonia in 

 human beings indicates the moment at which the pois- 

 onous products, manufactured by the bacteria located 

 in the lungs, are present in the circulation in amounts 

 sufficient to stimulate the tissues to the reaction that 

 results in the production of the antidotal substance that 

 has the power of rendering the poisons inert. 



At the time of the crisis in pneumonia the bacteria 

 themselves are in no way affected. They remain in the 

 lungs, and can be detected, in full vigor and virulence, 

 in the sputum of patients a long time after the disease 

 is cured. They have lost none of their power of pro- 

 ducing poisonous products, and still possess their orig- 

 inal pathogenic relations toward susceptible animals. 

 It is only after the crisis that their poisons are neutral- 

 ized by this antidotal proteid that has been produced 

 by the cells of the tissues, and as this occurs the sys- 

 temic manifestations gradually disappear. The Klem- 

 perers claim to have isolated from cultures of micro- 

 coccus lanceolatus a proteid body that is the agent con- 

 cerned in producing the tissue-reaction which results in 



