74 Freclerick Mott 



beUveen death and the fixation of the tissue. They are, however, found 

 most abundantly in Dementia Senilis, General Paralysis, Amaurotic 

 Idiocy, and Dementia Praecox. They may be regarded as evidence of 

 defective oxidation processes and hypofunction. They cannot be wholly 

 due to post mortem changes ¡n Dementia Praecox, for the h'poid can be 

 seen in the perivascular lymphatics. 



The result of chemical analysis of the brain in Dementia Praecox 

 shows a deficiency in neutral sulphur, which also points to defective oxi- 

 dation processes (Koch and Mann). These facts may be correlated with 

 the tendency to an acidophile reaction of the nuclear substance, which 

 indicates a deficiency in the organic phosphorus. A similar condition 

 occurs also in the nuclear substance of the testis especially affecting the 

 spermatogenic cells. According to Heidenhain this oxychromatin colour 

 with eosin and blue dyes signifies a diminution of organic phosphorus, 

 this diminution of organic phosphorus may be associated with diminished 

 function in relation to oxidation processes (figs. 1-8). 



The Gonads. Male. 



A. Spermatogenesis. — Spermatogenesis has been compared in io8 

 cases dying in hospitals and asylums at different ages and in different 

 bodily States, including normal death from shock of injury. 



Normal. — It has been found active from puberty to oíd age (8lj with 

 individual variations in degree. 



General Diseases. — In cases where severe chronic disease occurred 

 in early life, there has been found absence or deficiency of spermato- 

 genesis. 



In adults dead of shock following accident, tuberculosis, dysentery, 

 bronchopneumonia, enteric fever, gangrene of lung, active spermatoge- 

 nesis was found. It was absent in several cases of prolonged extensive 

 suppuration, and in several cases of cáncer. But these were diseases in 

 which an active prolonged nuclear proliferation had taken place. 



. General Paralysis. — In general paralysis local patches of atrophy with 

 dense fibrosis ocurred in many of the cases examined, but with very few 

 exceptions in a large number of cases active spermatogenesis in all stages 

 was found in spite of intercurrent disease. The atrophied patches were 



