8o Frederick Mott 



reproductive organ of a failure of nuclear productive energy of the 

 gonads. 



Infernal Secretion. — As there is a progressive failure of the primitive 

 follicles to niaturate and to disappear and be replaced by dense fibrous 

 tissue, it foUows that the thecal cells and the cells of the granulosa do not 

 form, consequently the internal secretion which is a product of the acti- 

 vity of one or both of these structures must also fail correspondingly. 



Other Endocrine Glands. — No constant changes have yet been esta- 

 blished. 



Cases of hypothyroidism shewing pituitary and ovarían change have 

 shewn a diminished basophile reaction in the neurones of the cortex, as- 

 sociated in some cases with an acate psychosis. 



The suprarenal glands have shewn in a large number of cases of De- 

 mentia Praecox a diminished lipoid content. This change is not a spe- 

 cific one, although the connection between these glands and the gonads 

 is undoubted. 



Acute dementia praecox. 



A remarkably interesting, fatal case of acute Dementia Praecox has 

 recently come under my observation and since it strongly supports the 

 conclusión that this disease is of biogenetic origin, I will describe it in full. 



M. N. — Aged 19 admitted Claybury Asylum 10, II, 21 died 21, 

 II, 21. 



Family History. — Paternal Heredity. — Father insane, died in a priva- 

 te asylum — Father's sister one of 12, insane. 



Maternal Heredity. — Grandmother Diabetes, Grandfather insane, Mo- 

 ther's brother one of 9, ñas insane. 



He is one of a family of 5. One brother died of bullet in brain, ? ac- 

 cident or suicide. A sister suffering with recurrent insanity admitted to 

 asylum for the 4th time with sex delusions. Brother and sister who vi- 

 sited patient normal. 



Personal History. — Intelligence above the average and a good athlete. 

 Nothing noteworthy in early life beyond normal infantile diseases. Tem- 

 peramentally he was optimistic and cheerful. 



Present Illness. — He had been working hard for his examination; a 

 week before the examination he suffered from insomnia, and at the time 



