84 



Fredeiick Mott 



Sections from the same regions were cut in paraffin of 5 fi thickness 

 and stained by Nissl method, by polychrome and by toluidin blue and 

 eosin and mounted in Canadá Balsam. 



Changes in the nucleiis of the ganglion cells. — The nuclei are greatly 

 swollen and cause a distorted shape of the cell; this is most marked in 

 the small pyramidal cells of the cortex and the polymorph layer and espe- 

 cially are the stellate layers of cells of Cajal affected. The nuclei of these 

 cells are much swollen and very palé (vide figs. 5 and 6). The cytoplasm 



Fig. 5. — Photomicrograph I. — Section of Ascending Parietal Convolution stained 



by Nissl method showing large pyramidal cells beneath which is the granule layer 



of stellate cells, mostly the small type, and with swollen nuclei and very palé 



staining. Magnification 160. 



can hardly be seen owing to the svvelling of the nucleus; there are vacuo- 

 Íes in it owing to the lipoid having been dissolved out. Many very palé 

 neuroglia cells can be seen in all regions of the cortex, and groups can 

 be seen adhering to or coUected arouhd degenerated cells (fig. 6). 



Nissl Granules. — Very few even of the large cells of the cortex, the 

 basal ganglia, pons, medulla, or spinal cord, show a proper pattern of 

 Nissl granules. Usually there is a crumbling of the granules, and a ten- 

 dency for the basophile substance to appear as a dust. The nucleus of 

 the multipolar cells of the spinal cord, pons, and medulla, and the large 

 Betz cells show less change, and there is a fair amount of basophile subs- 

 tance. It is the smaller cells of the brain in which the nuclear swelling 



