The genetic origin oí Dementia Praecox 



85 



is most marked, that Ihe basophile stainable substance ¡s most deficient 

 (figures 5 and 6). 



The cells when stained by polychrome or toluidin blue and eosin 

 show a micro-chemical change. The nuclear membrane and the intra- 

 nuclear network have lost their delicate and clear blue thread Hke appea- 



tv?J 



Fig. 6.— Section of Frontal lobe stained by original Nissl method. A group of 

 4 iarge stellate cells showing vacuolation'of cytoplasm, due to lipoid granules 

 having been dissolved out. The nuclei are greatly swollen. Adherent to one cell 

 are palé glia cells. Beneath are two stellate cells, which on account of the great 

 Hwelling of the nucleus have lost their stellate form and the finely vacuolated 

 cytoplasm is hardly seen. Magnification i.ooo. 



ranee. The threads of the network are of a faint purple colour and thick 

 er than normal; the nucleolus instead of being a deep blue is purple or 

 often pink, indicative in the former case of a partial, and in the latter of a 

 complete acidophile reaction. 



To sum up, there are morphological and niicrochemical changes 

 in the brain indicative of an acute nuclear degenerative change wluch 



