86 , Frederick Mott 



can only be accounted for by a primary biogenetic failure of dura- 

 bility. 



The Testes. — Frozen sections stained with Scharlach and haematoxy- 

 lin showed abundance of interstitial lipoid and lipoid granules in the cells 

 of Sertoli, both ¡n those tubules where spermatogenic epithelium was 

 still present, and in those in which the Sertoli cells were alone present. 

 (vide figs. 7 and 8, A). Haematoxylin-eosin preparations mounted in Ca- 

 nadá Balsam showed tubules in all stages of primary regressive atrophy. 



Fig. 7. — Section of testes stained haematoxvlin eosin. Five tubules are seen 

 in which there is complete or almost complete regressive atrophy. There is a 

 dense interstitial fibrosis. There are other tubules in which spermatogenesis can 

 be seen but which upon higher magnification show the process to be incomplete 

 (vide fig. 8). Magnification 1 10. 



Spermatic Tubules; in some of the tubules only a thickened basement 

 membrane exists lined by Sertoli cells, in others there are all stages of 

 regressive degenerative atrophy of the spermatogenic epithelium shown 

 by a failure of nuclear chromatin in spermatogonia, spermatocytes, and 

 spermatids (vide fig. 8). Where spermatids and spermatozoa are seen, 

 there is evidence of a micro-chemical change; many of the heads of the 

 spermatozoa have not a lance head shape, and many give a marked aci- 

 dophil reaction corresponding to the condition which I have tound in 

 other cases. 



Sections stained by the Hortega method showed the heads of the 

 spermatozoa, but although the staining was very successful iunlike sec- 



