A LECTURE 



THE AKTIFICIAL PRODUCTION OF TUBERCLE IN THE LOWER ANIMALS. 



Me, President and Gsentlemen, 



The nature and relations of tubercle liave of late received such able 

 and elaborate illustration in this College, both by Dr. Andrew Clark in 

 the Croonian Lectures, and by Dr. Southey in the Gulstonian Lectures, 

 of last year, that I should not have presumed again to call attention 

 here to this subject, had not the question received within the past year 

 some new and, as it appears to me, most important additions, through 

 experiments conducted by myself and others on the artificial production of 

 the disease, which I cannot but deem to be deserving of the serious con- 

 sideration of the able and independent observers whom this College numbers 

 among its members. 



The genesis of tubercle, although long involved in profound obscurity, 

 has nevertheless been constantly and repeatedly a subject of experiment by 

 some of the most illustrious pathologists of the past and present century. 



Thus, Baron' stated that the first Dr. Jenner had observed that rabbits 

 could be made tuberculous by submitting them to a special kind of diet. 

 That the appearances thus produced were due, however, only to hydatids 

 is seen by an illustration of Sir R. Carswell's,^ where the affection of the 

 liver is shown now to be due to entozoic disease. It must, however, be 

 remembered that Baron, and probably Jenner, attributed to hydatids an 

 important part in the production of tubercles. 



^ Inquiry illustrating the Nature of Tuber- ^ Illustrations of the Elementary Forms of 

 culated Accretions, 1829, pp. 96, 97. Disease. " Tubercle," pi. ii fig. 6. 



B 



