4 ARTIFICIAL PRODUCTION OF TUBERCLE. 



are followed by the production of a disease which we consider tuberculous ; 

 and the results of my own observation, which I have now the honour to lay 

 before you, confirm Dr. Sanderson's views, which he published at the Patho- 

 logical Society a few weeks since. 



The only other experiments which here require allusion have been some 

 recently made by Professor Lebert,^ on the introduction of matters into the 

 circulation ; and to these I shall have again to refer. 



As regards my own experiments, I have inoculated with various materials 

 117 guinea-pigs, and 12 rabbits. Of the 117 guinea-pigs, 58 have proved 

 tubercular, 6 have yielded doubtful results, and no effect was produced in 53. 



In order to save time, and prevent a wearisome repetition of figures, 

 I have tabulated the results which I have obtained. 



I wish to explain that I have placed those cases only in the category 

 of tubercle in which, in addition to local effects, or to the implication of the 

 neighbouring lymphatic glands, three or more of the following organs have 

 been found to be simultaneously affected ; viz. the lungs, the bronchial glands, 

 the liver, spleen, omentum, mesentery, and intestines. When this has been 

 the case, I have tabulated the result as successful; when only one or two, 

 as doubtful ; when none, as failure. In the next columns, I have stated the 

 duration of life, and in many cases whether the animals died or were killed. 

 In another column I have placed what I consider a very interesting 

 point ; viz., the number of times in which there has been what I shall explain 

 as a local production of tubercle. Unfortunately my notes do not in all 

 cases contain a statement of this fact. 



1 Virchow's Archiv, vol. xl. 



