ARTIFICIAL PRODUCTION OF TUBERCLE. 7 



dried-up debris of fattily degenerated material, rather than true puriform 

 cells. The most common effect by far is the production of this cheesy matter 

 under the skin. It is usually encapsuled; and sometimes there are two or 

 three such masses, distinct from one another, or they may be more numerous, 

 and may, together with the granulations next to be described, be found at 

 considerable distances from the site of the inoculation. Thus in one instance 

 they extended two-thirds of the length of the spinal column, and caused 

 death through paralysis consequent on their pressure producing erosion of 

 the bodies of two vertebrae, and subsequent softening of the spinal cord. In 

 another case I found a rib similarly injured, but in neither of these instances 

 was there any distinct tubercular change in the bone. The capsule of these 

 masses is firm, semi-transparent, almost lardaceous in appearance; it passes 

 insensibly into the surrounding tissue. 



In addition, however, to these cheesy changes, another set of appearances 

 are seen around the seat of injury. These are small granulations, varying 

 in size from a poppy-seed, or even smaller, to that of a hemp-seed, which are 

 irregularly scattered for a variable area in the subcutaneous tissue. They 

 are sometimes semi-transparent throughout ; sometimes yellow and opaque 

 throughout ; sometimes yellow in the centre, with a semi-transparent margin. 

 Larger masses, of the size of a pea, are sometimes also found, apparently 

 presenting intermediate gradations between these and the larger cheesy masses : 

 for they are cheesy in some parts, and indurated in others ; and they present 

 a striking resemblance to the naked eye, and also under the microscope, to 

 the changed lymphatic glands. These larger granulations are most commonly 

 found near the seat of injury. The smaller granulations are often scattered 

 on the outside of the capsules of the larger cheesy masses ; but they may 

 extend to great distances beyond this, sometimes in lines and rows, sometimes 

 in scattered circles, and in little groups. They often reach up to the neigh- 

 bouring lymphatic glands, and are grouped in masses of variable size around 

 these (Plate I. fig. 6). 



In addition to these, cords of induration are seen extending, at variable 

 depths and for variable distances, through the subcutaneous and muscular 

 tissues. The cords are firm and semi-transparent, like gristle ; but their central 

 portions are often cheesy. Sometimes they form varicose dilatations, reaching 

 up to the lymphatic glands. Sometimes cords extend through the lymphatic 

 glands into the surrounding tissues : whether from or to the gland, it is 

 difficult to say (Plate I. fig. 7). 



The cords are not constant, nor are the granulations, but the frequency 

 with which they occur is very considerable. The granulations have not been 



