U ARTIFICIAL PRODUCTION OF TUBERCLE. 



greatly increased in weight. This organ also presents various appearances. A 

 very common one is, that small whitish spots are scattered thickly through the 

 whole tissue. These appear of about twice the size of the normal Malpighian 

 bodies. Another consists of agglomerations of these rounded bodies into 

 masses, which have then a racemose appearance. 



Other masses are seen more opaque, but having the same structure of 

 agglomerated granules. The spots of smaller size have generally a certain 

 transparency, but less than is observed in the liver or in the lung. Sometimes 

 large tracts of the spleen are converted into a semi-transparent brittle tissue 

 resembling that of the liver or of the lymphatic glands, and showing also an 

 appearance as if originally composed of fine granulations. 



Various forms of cheesy change are also found. These in some places 

 occupy about the same area as the smaller granules, and are seen as scattered, 

 yellow, dry, firm spots, brittle, and crumbling under pressure into a granular 

 mass. The larger compound granulations may similarly become cheesy and 

 opaque. Cheesy spots, of variable size, may also be seen scattered through the 

 semi-transparent tissue. In rarer cases, large irregular tracts may become 

 cheesy, but still maintaining the same firm, dry, friable, and opaque character. 

 In yet rarer instances, large portions of the spleen are found changed, like 

 those of the liver, into masses of the size of a hazel-nut (which is the largest 

 I have seen), and composed of a diffluent softened amorphous material ; but, 

 in such cases, semi-transparent granulations and cheesy granulations are seen 

 in other parts of the organ. 



The large cheesy masses are not very distinctly separated from the 

 surrounding tissue, and are not surrounded by any zone of injection. They 

 differ also considerably in the character of the softened material and ia the 

 absence of abruptness in their limitation from anything known as pysemic 

 spots. Under the microscope, most of the granulations seem to be composed 

 of enlarged Malpighian bodies undergoing various stages of fatty degenera- 

 tion. The whole tissue is also infiltrated with cells precisely resembling the 

 lymphatic cells of the spleen. Togetlier with this increase of cells, there may 

 be found, in the more transparent areas, fibrous changes analogous to those 

 described in the lymphatic glands. 



The changes in the intestines mostly aff'ect the small intestines and the 

 caecum. In the former, the patches of Peyer are enlarged, and they are 

 prominent externally. The peritoneal surface is injected, and sometimes 

 thickened, and through it numerous opaque white spots can be seen. Inter- 

 nally, also, the patches are enlarged and prominent, and the mucous membrane 

 around is injected and opaque. Milky -white spots are seen scattered in the 



