CONTENTS 11 



The possible hypotheses 146 



Experimental proofs of the living nature of the bacteriophage 149 



Refutation of the hypothesis of Kabeshima 153 



Refutation of the hypothesis of Bordet and Ciuca 154 



Refutation of the hypothesis of Bail 158 



Refutation of the hypothesis of Salimbeni 159 



Conclusions 159 



PART II. THE ROLE OF THE BACTERIOPHAGE IN IMMUNITY 

 Introduction 163 



Chapter I. The Bacteriophage in Disease 



Choice of diseases to study 173 



Bacillary dysentery 176 



Colon bacillus infections 189 



Typhoid fever and the paratyphoid fevers 189 



Avian typhosis 204 



Hemorrhagic septicemia of the buffalo (barbone) 217 



Bubonic plague 224 



Flacherie 227 



Conclusions 228 



Chapter II. The Bacteriophage in the Healthy Individual 



The bacteriophage in healthy man , 229 



The bacteriophage in the horse 233 



The bacteriophage in the fowl 236 



The bacteriophage in diverse animals 237 



Conclusions 239 



Chapter III. Immunization by Means of the Bacteriophage 



Immunization against avian typhosis 242 



Immunization against barbone 248 



Immunization against dysentery 262 



Chapter IV. The Bacteriophage and Immunity 

 Summary and conclusions 272 



* * * * 

 Bibliography 283 



