44 LOCALIZATION OF MICRO-ORGANISMS. 



incipient inflammation induced by it. Similar results were ob- 

 tained by Frankel and Siinger (" Untersuchungen liber die Aetio- 

 logie der Endocarditis/ 7 Centralblatt f. klinische Medicin, 1886, p. 

 577). 



Rinne (" Der Eiterungsprocess und seine Metastaseu," Archiv /. 

 kiln. Chirurgie, B. 39, p. 19) injected pure cultures of the different 

 kinds of pus-microbes directly into the circulation in animals, and 

 found that, as a rule, no harm resulted. In rabbits he injected 

 from two to three Pravaz's syriugefuls of uufiltered and filtered 

 suspension of pure cultures in distilled water, and after repeating 

 the injections several times inflicted all kinds of subcutaneous 

 lesions without causing serious disturbances. Only in a few in- 

 stances were pysemic metastases observed, and this occurred usually 

 only in cases where undiluted gelatin cultures were used. In 

 several dogs he made subcutaneous fractures and then injected fluid 

 cultures of pus-microbes in large doses into the peritoneal cavity, 

 but no suppuration occurred at the seat of injury. In six rabbits 

 he fractured the femur subcutaueously, and then injected pure cul- 

 tures into the jugular or one of the auricular veins, but in only 

 one of them did the seat of fracture suppurate, and in this case no 

 other metastases were discovered. In two experiments where he 

 injected osteomyelitic pus diluted with distilled water suppuration 

 was produced at the seat of fracture and at the same time abscesses 

 were found in the heart-muscle and the kidneys at the autopsy. 



Roseubach ("Beitriige zur Kenntniss der Osteomyelitis/' Deutsche 

 Zeitschrift / Cliirurgi'e, 1878, p. 369) ascertained that acute sup- 

 purative osteomyelitis in animals could only be produced experi- 

 mentally by injecting pus directly into the circulation and by 

 injuring the medullary tissue a few days before, or after, the inocu- 

 lation. Kocher (" Die acute Osteomyelitis mit besouderer Riick- 

 sicht auf ihre Ursachen," Deutsche Zeitschrift/. Chirurgie, 1879, p. 

 87), Becker (" Ueber die Osteomyelitis erzeugeudeu Mikroorgan- 

 ismen," Deutsche med. Wochenschrift, 1883, No. 46), and Krause 

 (" Ueber einen bei der acuten infectiosen Osteomyelitis beim 

 Menschen vorkommenden Micrococcus," Fortschritt. der Medicin, 

 1884, B. ii. No. 7) repeated the experiments of Rosenbach and 

 came essentially to the same conclusions. Both Kocher and Rosen- 

 bach look upon the altered circulation in the injured tissues as the 

 condition which determined localization, while they admit that the 

 immediate tissue lesions, hemorrhage and necrosis, might have the 

 same effect. Upon the same hypothesis Kocher (" Zur Pathologic 

 u. Therapie des Kropfes," Deutsche Zeitschrift f. Chirurgie, 1878, B. 

 x. p. 189) explained the occurrence of traumatic suppurative stru- 

 mitis in a hyperplastic struma. 



Ribbert (" Die Schicksale der Osteomyelitiskokken im Orgauis- 



