LOCALIZATION OF MICKO-ORG ANISMS . 53 



tive results. In 7 experiments in which the stomach was irritated 

 by chemicals before the feeding of the culture was commenced, 6 

 animals remained well, and in the one that died the microbes had 

 not passed beyond the prima via, as the blood and internal organs 

 were found sterile. Of 12 animals in which the pure culture was 

 injected into the healthy bronchial tubes, 9 were killed one-half of 

 an hour to 11 days after the injection, and 3 died. In the animals 

 which were killed no trace of microorganisms could be found in 

 the blood, they had not passed beyond the lung tissue. In the 3 

 fatal cases the animals died 17, 25, and 70 hours after the injec- 

 tion, and the microbes could be found in nearly all of the internal 

 organs and the blood. In the 2 cases in which the trachea had 

 been altered by traumatic irritation, the animals were killed 24 and 

 25 hours after inoculation, and on examination it was seen that the 

 infection had remained local. In 6 experiments in which the bron- 

 chial tubes were irritated with a solution of nitrate of silver 6 

 hours before inoculation, the animals died 20, 24, 40, and 48 hours 

 after the injection, having before death shown evidences of serious 

 pulmonary trouble. The post-mortem showed in all of them pul- 

 monary oedema and pleuritis, but staphylococci were found in only 

 2 of them in the effusion. In 6 animals fed on the culture, in 4 

 on a healthy stomach and in 2 after an artificial gastro-intestinal 

 catarrh had been produced, he made a subcutaneous fracture, and 

 suppuration followed at the seat of the fracture. He believes that 

 in all cases in which the microbes entered the circulation the en- 

 trance was effected through some perhaps inappreciable lesion. 



Gussenbauer (Deutsche Chiruryie von Billroth u. Luecke, Lief. 4, 

 p. 126) describes one of those cases which are not of infrequent 

 occurrence where recovery after an attack of suppurative lymphan- 

 gitis was followed by a phlegmouous inflammation in the axilla. 

 The patient was twenty-five years old, in good health otherwise, 

 when he contracted after a slight injury of the hand a lymphangitis 

 and lymphadenitis of the arm and axilla attended by circumscribed 

 gangrene of the skin and flexor tendons. The lymphatic glands 

 did not suppurate but remained slightly enlarged. Suppuration 

 continued for eight weeks when recovery was complete and the man 

 remained in good health for eight months. At this time he suffered 

 from an acute abscess in the axilla of the same side which could 

 have been only caused by the pus-microbes which had remained in 

 the enlarged lymphatic glands since the first attack. Smirnoff has 

 recently published an interesting dissertation (St. Petersburg, 

 1889), in which he describes his examinations of syuovial fluid 

 removed from joints. Pie has found that not infrequently in the 

 course of an infectious disorder the pathogenic microbes may be 

 detected in the synovia. He examined 51 cases including erysipelas, 



