PUS-MICKOBES IN SUPPUEATIVE AFFECTIOXS. 105 



intravascular growth and general dissemination from such centres 

 of germ growth take place. 



In some cases even during the earliest stages the general symp- 

 toms are out of all proportion to the local lesion, presenting a clini- 

 cal picture characteristic of intense septic intoxication. It is very 

 possible that the ptomaines produced by the pus-microbes in the 

 medullary tissue of bone may be more virulent or produced in 

 larger quantities than in suppurative inflammations in other organs. 

 Again, the ptomaines gain here more ready entrance into the circu- 

 lation, as, at least, part of them are produced within the bloodvessels 

 and the extravascular products are forced rapidly into the circula- 

 tion on account of the unyielding nature of the tissues around the 

 primary focus of inflammation. 



