INOCULATION FOE THERAPEUTICAL PUEPOSES. 131 



successful inoculation. The period of incubation was fixed at 

 from fifteen to sixty-one hours. The microbe was only found in 

 the lymphatic vessels and connective-tissue spaces, and when the 

 culture was pure never produced suppuration. 



Whitney (" Notes on Blood-changes in Erysipelas," Philadelphia 

 Medical Times, 1883) claims that he found the streptococcus 

 erysipelatosus in the blood in five out of six cases of erysipelas. 

 Most all authorities who have studied the subject with the greatest 

 care assert, however, that it is only found in the lymphatic vessels 

 and never in the bloodvessels. 



INOCULATION FOR THERAPEUTIC PURPOSES. Fehleisen has 

 seen by this treatment a cancer of the breast become smaller, a 

 lupus disappear almost completely, while a case of fibro-sarcoma 

 and another of sarcoma were not materially affected by this method 

 of treatment. 



Kleeblatt (Munch, med. Wochenschrift, March, 1890) reports the 

 case of a lympho-sarcoma followed by infection of the cervical 

 glands, in which the tumors diminished markedly in size under 

 the influence of an intercurrent attack of erysipelas, but continued 

 to develop after this had passed off. The patient was afterward 

 intentionally inoculated with a pure culture of the streptococcus of 

 erysipelas, but the effect was, as before, only a temporary one, as the 

 tumors steadily increased in size, the patient dying of exhaustion. 

 In another case of lympho-sarcoma of the neck, erysipelas was 

 inoculated with good results, as the tumor was found to have dis- 

 appeared on recovery from the disease. In a third case of lymph- 

 adenoma of the lower eyelid, the size of a pigeon's egg, this suppu- 

 rated during an intercurrent attack of erysipelas, and afterward 

 disappeared completely. 



Jauicke and Neisser ( u Exitus letalis nach Erysipelimpfung bei 

 inoperablem Mamma-carcinom und microscopischen Befund des 

 geimpften Carcinoms," Centralblattf. Chirurgie, 1884) have recorded 

 a death from the erysipelas thus intentionally produced, in a case 

 of cancer of the breast beyond the reach of an operation. A pure 

 culture was used. At the post-mortem it was proved that the neo- 

 plasm had almost completely disappeared, and the microscopical 

 examination of portions that had remained appeared to show that 

 the tumor cells had been destroyed through the direct action of the 

 microbes. Biedert (Vorlaufige Heilung eiuer ausgebildeten Sar- 

 comwucherung in einem Kinderkopf durch Erysipel," Deutsche 

 med. Zeitung, 1886, No. 5) saw in a child suffering from a sarcoma 

 involving the posterior part of the cavity of the mouth and pha- 

 rynx, the left half of the tongue, the naso-pharyngeal space and 

 the right orbit, the tumor disappear almost completely during an 

 attack of erysipelas. Cases, on the other hand, have been reported 



