PKOPHYLACTIC AND CURATIVE TREATMENT. 155 



chloral hydrate given internally. The patient died twelve hours 

 later. In the other case, the patient had run a splinter into her 

 foot between the great and second toe while following a path bare- 

 footed over a field. Six days later tetanus made its appearance, 

 the splinter was removed, and the wound treated as in the preced- 

 ing case; death four days later, ten days after the injury. 



In the first case Sormani inoculated two rats and one rabbit with 

 the tissue which was removed from the wound before dusting with 

 iodoform. All these animals died from tetanus from forty-eight to 

 ninety-six hours after inoculation. Two rabbits inoculated with a 

 fragment of tissue from the wound after the death of the patient 

 remained alive. 



In the second case a piece of the iodoformized tissue and one 

 from the tissues lying more deeply were used for inoculation of two 

 rats, which, however, did not contract the disease. A culture-glass 

 filled with agar inoculated with a fragment of the wound-tissues 

 after the disinfection remained sterile; another tube inoculated with 

 tissue removed more deeply developed staphylococci. 



The author concludes, from these and further experiments, that 

 where tetanus is already developed iodoform is not able to prevent 

 its further course, but may neutralize the virus on the surface of 

 the wound. 



Baccelli (Riforma Medica, January 25, 1890) used subcutaneous 

 injections of carbolic acid in doses of 1 centigramme every hour. 

 In 1887 he cured a grave case, and now he has another such a one 

 under treatment, where the injections have produced such an im- 

 provement that recovery is assured. 



