162 TUBEKCULOSIS. 



localization does not always take place at the point of primary 

 infection. 



Mr. Eve (" On the Relation of Scrofulous Gland Disease to other 

 forms of Tuberculosis ; an Experimental Inquiry," British Medical 

 Journal, April 14, 1888) conducted some experiments for the same 

 purpose, using small fragments of the glands prepared with steril- 

 ized instruments, and the possibility of infection of the animals 

 with true tuberculosis was negatived by the precautions taken. As 

 regards the results of the experiments on rabbits with glands from 

 five different subjects, the material from these cases produced vis- 

 ceral tuberculosis; from one case, cold abscesses; and in one 

 instance, in which a rabbit was inoculated in the anterior chamber 

 of the eye, it escaped infection altogether. No bacilli could be dis- 

 covered in the gland. Three rabbits inoculated with the infected 

 organs from a guinea-pig, proved to be the most acute cases of 

 tuberculosis that the author has been able to induce by strumous 

 gland disease in rabbits, the tubercles being widely disseminated. 

 The bacilli in the visceral tuberculosis were generally uniformly 

 stained with even outlines, but in a strumous abscess in a rabbit 

 which had existed for eight months they were nearly all "beaded" 

 or uniformly stained, and often collected in groups not unlike 

 clumps of micrococci. 



Wm. Mueller (" Experimentelle Erzeugung der typischen 

 Knochentuberculose," Centralblatt f. C/iirurgie, 1886, p. 233) pro- 

 duced the characteristic form of tuberculosis in bone experimentally 

 by the injection of tuberculous material into the nutrient artery. 

 Konig for a long time had claimed that the wedge-shaped seques- 

 trum so constantly found in tubercular foci in the articular extremi- 

 ties of the long bones, was due to occlusion of a small artery by a 

 tubercular emboltis. Miiller's experiments were made to prove 

 this clinical observation. He made sixteen experiments on rabbits, 

 injecting tuberculous pus into the femoral artery, some in a periph- 

 eral, some in a central direction, without any positive results. In 

 a second series the same material was thrown into the nutrient 

 arteries of the femur and tibia. Of ten of these cases, two showed 

 a tuberculous focus in the medulla of the diaphysis of the tibia, in 

 another case miliary tuberculosis in the femur and tibia, and in the 

 latter bone a small caseous spot in the spongy part, which contained 

 numerous bacilli. The animals were killed eight weeks after the 

 injection and showed no evidences of organic disease, except few 

 tubercles in the lungs. Twenty experiments were made on young 

 goats, five on sheep, and two on .dogs. The tuberculous material 

 was injected directly into the nutrient artery of the tibia, the tibial 

 artery being tied above and below this vessel. Primary union of 

 the wound was obtained in all cases except on one dog. 



