INOCULATION-TUBERCULOSIS. 163 



In the dogs and sheep, all experiments yielded negative results. 

 In the goats bone affections were produced which were identical 

 with tubercular bone lesions found in man. Most frequently the 

 disease was established in the diaphysis cheesy masses and granu- 

 lation tissue showing themselves in the medulla and cortical sub- 

 stance, or tuberculous osteomyelitis with, or without, sequestration. 

 Typical lesions were also found in the ends of the bones with, and 

 without, implication of the adjacent joints. In two of these cases 

 the epiphysis was affected, while in three the shaft was involved. 

 The following experiment furnishes a good illustration of the iden- 

 tity of the bone disease produced experimentally, and the disease 

 as it occurs in man. Tuberculous material was injected into the 

 tibial artery of a goat three months old. Wound healed in eight 

 days. Some lameness four months later, gradually increasing dur- 

 ing the next nine months. At the same time a swelling appeared at 

 the knee-joint. Tibia painful on outer side. Animal killed thirteen 

 months after the injection. There was found a typical fungous 

 disease in the knee-joint most advanced at the sides, a wedge-shaped 

 sequestrum in one of the tuberosities of the tibia, and a small 

 granulation mass in the centre of the head of the tibia, and two 

 similar granulation masses in the lower epiphysis of the femur. 

 With the exception of the lymphatic glands of the knee joint, no 

 other organs were affected. In some cases pulmonary tuberculosis 

 developed, twice general tuberculosis. The rest of the animals 

 were killed when they began to show lameness fourteen days to 

 thirteen months after the inoculation. The tubercular lesions thus 

 produced were examined for bacilli and these were never found 

 absent. The starting-point in every instance must have been a 

 tubercular embolus in one of the small arterial branches in the 

 extremity of the bone. 



The opinion that tubercle is capable of inoculation was held by 

 many ancient writers, and Laennec himself, after a nick from a saw 

 while making a necropsy on a phthisical subject, thought that he 

 witnessed an example of inoculation in a small tubercle in the skin, 

 but twenty years afterward this great physician and teacher was in 

 good health, though finally he died of phthisis. 



Inoculation-tuberculosis. 



Schmidt ( u Uebertragbarkeit der Tuberkulose durch cutaue Imp- 

 fung," Milnchen. drtzliches Intelliyenzblatt, 1883, Nos. 47 and 48) 

 made a number of experiments to ascertain the effect of inoculations 

 of superficial abrasions of the skin with the virus of tuberculosis. 

 In guinea-pigs he made slight cutaneous abrasions of the skin to 

 which he applied tubercular material, and covered the point of 



