206 ANTHKAX. 



into the subcutaneous tissue around the carbuncle. The strongest 

 solution used consisted of 15 grammes of neutral glycerin and an 

 equal part of distilled water, in which 3 grammes of pure carbolic 

 acid were dissolved. The injections were made at five points around 

 the anthrax, and represented a total dose of 50 centigrammes of the 

 acid. The injections were painful, but rapid improvement followed. 

 This 10 per cent, solution was stronger than any previously em- 

 ployed for the same purpose by Boeckel, Kaimbert, and others. A 

 5 per cent, solution in ordinary cases is strong enough, but in grave 

 cases the 10 per cent, solution must be used until improvement 

 takes place, which may occur within forty-eight hours. 



Kaloif, of St. Petersburg, in making experiments with anthrax 

 on animals, accidentally infected himself, either by a needle punc- 

 ture or by handling the organs of anthracic animals. The local 

 infection appeared on the outer side of the thumb of the left hand 

 as a small vesicle, which disappeared soon, but gave place to circum- 

 scribed infiltration on the second day. This inflammation rapidly 

 extended and was surrounded with hemorrhagic vesicles. The in- 

 durated tissues were promptly removed by excision ; nevertheless, 

 on the next day swelling of axillary glands on the same side, fever, 

 great prostration, also diarrhoea. The skin in the axillary region 

 and the side of chest was much swollen, cedematous, and at different 

 points bright red, at others bluish-red. One of the axillary glands 

 the size of a hen's egg, and glands along the margins of the pector- 

 alis major were moderately enlarged. All the enlarged glands were 

 removed and the field of operation thoroughly disinfected with 

 solution of carbolic acid, and the same solution thrown into the 

 surrounding tissues with a hypodermic syringe. Cessation of fever 

 and rapid healing of wound, followed by recovery. Implantations 

 of fragments of excised glands in bouillon and gelatin yielded 

 cultures of anthrax bacilli. Excision of infected tissue and use of 

 carbolic acid strongly recommended. 



