Pathogenesis 411 



days. Frequent transplantation enabled Davis to carry 

 them on to the eleventh cultural generation. 



Pathogenesis. The organism is pathogenic for man 

 and certain monkeys (macacus), but not for the ordinary 

 laboratory animals. The organism can be found in large 

 numbers in both the genital and extra-genital chancroidal 

 lesions, and usually in small numbers in the pus from chan- 

 croidal buboes. It has not been encountered elsewhere. 

 Lenglet* isolated the organism in -pure culture, and by 

 inoculation with his cultures reproduced the lesions in man. 



*"Bull. Med.," 1898, p. 1051; "Ann. de Dermatol. et de Syph.," 

 1901, t. n, p. 209. 



