4i8 



Glanders 



injection. A febrile reaction of more than 1.5 C. is said 

 be pathognomonic of the disease. 



Pathogenesis. That the bacillus is the cause of glanders 

 there is no room to doubt, as Loffler and Schiitz have suc- 

 ceeded, by the inoculation of horses and asses, in producing 

 the well-known disease. 



The goat, cat, hog, field-mouse, wood-mouse, marmot, 

 rabbit, guinea-pig, and hedgehog all appear to be susceptible. 

 Cattle, house-mice, white mice, and rats are immune. 



Fig. 123. Pustular eruption of acute glanders as exhibited on the day 

 of the patient's death, twenty-eight days after initial chill (Zeit). 



Lesions. When stained in sections of tissue the bacilli 

 are found in small inflammatory areas. These nodules can 

 be seen with the naked eye scattered through the liver, 

 kidney, and spleen of animals dead of experimental glanders. 

 They consist principally of leukocytes, but also contain 

 numerous epithelioid cells. As is the case with tubercles, 

 the centers of the nodules are prone to necrotic changes, but 

 the cells show marked karyorrhexis, and the tendency is more 

 toward colliquation than caseation. The typical ulcera- 

 tions depend upon retrogressive changes occurring upon 



