Specific Therapy 561 



inoculated. He also called attention to the slight risk the 

 inoculated run of being injured in case their vital resistance 

 is below normal, or they are already in the early stages of 

 the disease, or where the dose administered is too large or 

 the second vaccination given too soon after the first. 



In 1903 Wright* published new statistics on the subject, 

 and between 1903 and 1908 numerous references to the 

 subject appear in the " British Medical Journal," in the 

 "Lancet," and in the "Journal of the Royal Army Medi- 

 cal Corps," all favorable in their general attitude. A volu- 

 minous report of the subject as it has been investigated 

 by the Medical Corps of the British Army is now in process 

 of preparation. 



Specific Therapy. Walgerf reported 4 cases treated 

 successfully with a serum obtained from convalescent 

 patients. Ten cubic centimeters were given at a dose, and 

 the injection was repeated in one case with relapse. 



RumpfJ and Kraus and Buswell report a number of 

 cases of typhoid favorably influenced by hypodermic injec- 

 tions of small doses of sterilized cultures of Bacillus pyo- 

 cyaneus. 



Jez|| believes that the antitoxic principle in typhoid fever 

 is contained in some of the internal organs instead of the 

 blood, and claims to have obtained remarkable results in 

 1 8 cases treated with extracts of the bone-marrow, spleen, 

 and thymus of rabbits previously injected with the typhoid 

 bacillus. 



Chantemesse,** Pope, ft and Steelejf have all used serums 

 from animals immunized against typhoid cultures for the 

 treatment of typhoid fever, with more or less success. An 

 analysis of the results will, however, show them to be very 

 inconclusive. 



The serum prepared by Macfadyen, by crushing cul- 

 tures frozen with liquid air and injecting animals with the 



* "Brit. Med. Jour.," Oct. 10, 1903. 



f " Miinchener med. Wochenschrift," Sept. 27, 1898. 



J "Deutsche med. Wochenschrift," 1893, No. 41. 



"Wiener klin. Wochenschrift," July 12, 1894. 



|| "Med. moderne," March 25, 1899. 

 ** "Gaz. des H6pitaux," 1898, LXXI, p. 397. 

 ff "Brit. Med. Jour.," 1897, I, 259. 

 t| Ibid., April 17, 1897. 

 "Brit. Med. Jour.," April 3, 1903. 

 36 



