60 VACCINE AND SERUM THERAPY 



formulated, that the cells of the nervous system, 

 having become desensitised by the chloral, may have 

 lost their power to hold the haptophore group of the 

 tetanus toxin in firm combination, thereby enabling 

 the antitoxin to dissolve out the toxin from the cells, 

 with consequent neutralisation. In order to have 

 success from this method of treatment, it is necessary 

 to keep the patient in a more or less hypnotic con- 

 dition for some days, at the same time giving 

 frequent large doses of the antitoxin. 



Treatment with Cerebral Emulsion. — In view of 

 the great affinity of the substance of the central 

 nervous system for tetanus toxin, use should be made 

 of this substance in cases where the antitoxin is not 

 at hand. Fresh brain can nearly always be procured 

 from butchers' shops. An emulsion should be made 

 with physiological salt solution, and this substance 

 given subcutaneously. Krokiewicz recorded sixteen 

 cases in which use was made of this preparation, an 

 unfiltered emulsion being injected hypodermically. 

 Of the sixteen cases, thirteen recovered, three being 

 severe attacks. 



