HYOSCYAMINE SULPHATE 367 



Tinctura Hyoscyami. Tincture of Hyoscyamus. (U. S. & B. P.) 

 Hyoscyamus, 150 ; diluted alcohol to make 1,000. Made by mace- 

 ration and percolation. (U. S. P.) 

 Dose.— D., 3i.-iv. (4.-15.). 



The preparations of hyoscyamus are of rather uncertain strength. 

 The dose is generally two to four times that of similar belladonna pre- 

 parations. 



Succus Hyoscyami. Juice of Hyoscyamus. (B. P.) 

 Dose. — Same as tincture. 



Hyoscyamin^ Sulphas. Hyoscy amine Sulphate. 

 (C,H,3 N O3). H,S O, 



The neutral sulphate of an alkaloid obtained from hyo- 

 scyamus. 



Derivation. — Hyoscyamine is derived from -hyoscyamus 

 seed. The latter are treated with ether to extract fat, and 

 then distilled with alcohol and sulphuric acid. The liquid 

 residue is neutralized with caustic soda and precipitated 

 with tannic acid. The precipitate is mixed with lime and 

 extracted with alcohol. The resulting alcoholic solution is 

 first treated with sulphuric acid, then with caustic soda, and 

 finally with ether, which dissolves the alkaloid. The latter 

 is recovered by distillation. 



Properties. — White, indistinct crystals, or a white pow- 

 der, without odor, and having a bitter, acrid taste. Deli- 

 quescent in damp air. Soluble in 0.5 part of water, and 

 in 2.5 parts of alcohol; very slightly soluble in ether or 

 chloroform. 



Dose.—B.., gr.i.-ii. (.06-.12); D., gr.^-^ (.001-.002). 



Hyoscyamine Hydrobromas. Hyoscyamine Hydrobromate. 

 C,,H,3N O3H Br. (U. S. P.) 



The hydrobromate of an alkaloid obtained from hyo- 

 scyamus. 



Properties. — A yellowish-white, amorphous, resin-like 

 mass, or prismatic crystals, having, particularly when damp. 



