CINCHONINE SULPHATE 459 



mother liquors a,fter the crystallization of quinine sulphate, 

 by the same method as for quinine. 



Properties. — White, silky needles, odorless, and having 

 a very bitter taste ; permanent in the air. Soluble in 100 

 parts of cold water, and in 8 parts of alcohol ; in 7 parts of 

 boiling water, and very soluble in boiling alcohol ; also in 

 14 parts of chloroform and in acidulated water ; almost 

 insoluble in ether. 



Dose. — One-third larger than quinine sulphate. 



CiNCHONiNvE Sulphas. Cinchonine Sulphate. (CigH^jNjO), 

 H,SO, + 2 H,0. (U. S. & B. P.) 



Derivation. — Obtained from the mother liquors after the 

 crystallization of the sulphates of quinine, quinidine and 

 cinchonidine, by precipitation with caustic soda, washing 

 with alcohol to free it from other alkaloids, solution in 

 sulphuric acid, and by purification with animal charcoal, and 

 crystallization. 



Properties. — Hard, white, lustrous, prismatic crystals, 

 without odor, and having a very bitter taste. Permanent in 

 the air. Soluble in QQ parts of cold water, and in 10 parts 

 of alcohol ; in 13.59 parts of boiling water, and in 3.25 parts 

 of boiling alcohol. Also soluble in 78 parts of chloroform, 

 but almost insoluble in ether. 



Dose. — One- third larger than that of quinine sulphate. 



Cinchonidine Sulphas. Cinchonidine Sulphate. 

 (C,,H,,N,0), H,SO, + 3 H,0. (U. S. & B. P.) 



Derivation. — Procured from the paother liquors, after 

 the crystallization of quinine sulphate, by further con- 

 centration. Purified by crystallization from alcohol, and 

 finally from hot water. 



Properties. — White, silky, acicular crystals, without odor, 

 and having a very bitter taste ; slightly efflorescent on ex- 

 posure to air. Soluble in 70 parts of cold water, and in 66 

 parts of alcohol ; in 1.42 parts of boiling water, and in 8 parts 



