596 VEGETABLE DRUGS 



While 5 to 6 grains induce symptoms of poisoning in dogs, 

 J to 1 drachm has often failed to produce a fatal result. 

 Santonin is eliminated by the kidneys, increasing their 

 secretion, coloring an acid urine yellow, and an alkaline 

 urine purplish-red, or bloody hue. The humors of the eye 

 are stained yellow, occasioning yellow sight in man, — 

 xanthopsy. There is congestion of the heart, lungs and 

 nervous centres observed after death, but no gastro-enteritis. 

 Santonin is very slowly converted in the intestines into 

 sodium santoninate, and absorbed in this form. The best 

 treatment of poisoning is undetermined, but inhalations of 

 ether and enemata of chloral, together with laxatives, when 

 consciousness returns, are said to be useful. 'The administra- 

 tion of santonin should be followed or accompanied by that 

 of a cathartic. 



The drug taay be given to fasting dogs as follows : 



Hydrarg. Chlorid. Mitis. 



Santo'nini aa gr.v. 



Sacchari ad. 3 i. 



M. et div. in chart, no. x. 

 Sig. One powder tid. (for round-worms). 

 or : — 



Santonin! • gr.vi. 



01. Ricini f ii. 



M. 



Sig. Give one-third every third day (for round-worms). 



Santonin may be given in pill to dogs combined with 

 oleoresina filicis and areca nut. Santonin is not so com- 

 monly or successfully used in the treatment of round-worms 

 in horses, as turpentine and aloes, creolin, etc. A ball con- 

 taining 3 ii. of santonin and 3 i. of calomel, or a combination 

 of 3 iv. santonin and 1 pint of castor oil, are suitable pre- 

 scriptions for the horse. Santonin is often remedial in 

 incontinence of urine in young animals, when belladonna 

 fails, and is frequently beneficial in the treatment of 

 amaurosis. 



