148 



COLLOIDS IN BIOLOGY AND MEDICINE 



in respiration. I have no knowledge of researches as to whether the 

 H-ion concentration of water containing CC>2 is affected by ash-free 

 albumin. 



WOLFGANG PAULI and M. SAMEC* have commenced exhaustive 

 studies into the influence of albumins on the solubility of electro- 

 lytes. They employed a serum albumin solution which had been 

 dialyzed eight weeks and contained 2.23 per cent of albumin. All the 

 readily soluble electrolytes investigated showed a slight decrease in 

 solubility as compared with pure water. The solubilities were as 

 follows: 



Contrariwise, the solubility of difficultly soluble electrolytes was de- 

 cidedly increased by the presence of albumin. 

 The solubilities were as follows: 



Having in view the deposition of urates in gout, H. BECHHOLD and 

 J. ZiEGLER* 3 undertook exhaustive studies of the solubility of uric 

 acid and urates in electrolyte-free serum. Since even traces of 

 NaHCO 3 (in the case of uric acid) and Na salts (in the case of 

 Na-urate) may greatly influence the solubility, before dialysing the 

 serum, HC1 was added until the NaHCOs was completely neutra- 

 lized, and the last traces of Na salts were removed by repeated 

 additions of KC1. Each addition was followed by dialysis. In 

 this way the following solubilities of Na-urate and uric acid were 

 obtained in electrolyte-free serum albumin solution containing 7.6 

 per cent albumin (expressing the percentage in relation to the entire 

 quantity of protein in defibrinated blood serum) at 37 C. 



In 1000 gm. serum albumin solution (in 1000 gm. water): 



Uric acid, 549 to 668 mg 64. 9 mg. 



Monosodium urate, 476 to 568 mg 1200 to 1500 mg. 



