GROWTH, METAMORPHOSIS AND DEVELOPMENT 275 



It follows from this in contradiction to previous views that the 

 blood in gout is frequently supersaturated with monosodium urate. 

 According to the analysis of G. KLEMPEEER, MAGNUS-LEVY and 

 SALOMON, the uric acid content of the blood in gout varies between 

 30 and 80 mg. per liter, whereas in normal blood at most only 

 traces of uric acid can be demonstrated. When the content reaches 

 25 mg. of sodium urate per liter of blood serum, every further addi- 

 tion must be associated with a deposition of sodium urate, provided 

 urate nuclei are present. We thus see that the serum colloids are 

 of great importance for the solution of sodium urate in the blood 

 and in preventing its deposition in gouty processes. [STANLEY R. 

 BENEDICT in his Harvey Lecture, 1915-1916, p. 362, discusses the 

 presence of two forms of uric acid in blood. He determined ten 

 times the amount of uric acid originally obtained by the preliminary 

 boiling of the protein free filtrate with hydrochloric acid. The prob- 

 able destruction of a " protective" substance is quite apparent. 

 This aspect has an important bearing on uric acid determinations in 

 nephritis and out. Tr.] 



The influence on these processes exerted by radium emanations 

 which inhibit the deposition of sodium urate from supersaturated 

 serum (H. BECHHOLD and J. ZiEGLER* 4 ) deserves the attention of 

 students of colloids. 



