TOXICOLOGY AND PHARMACOLOGY 373 



The result of the experiment was as follows: unstabilized silver 

 hydrosol (prepared according to G. BREDIG) as well as collargol had 

 no action in small doses. Silver hydrosol (prepared according to G. 

 BREDIG), stabilized with gelatin, increased the nitrogen metabolism; 

 the nuclein metabolism was chiefly affected since there resulted a 

 decided increase in the elimination of uric acid in the urine. Sil- 

 ver hydrosol stabilized by gelatin has a more powerful action than 

 the corresponding quantity of silver nitrate, silver thiosulphate or 

 silver albuminate, which exert a qualitatively analogous action. 

 On the other hand, the N elimination in the feces is decreased. 

 Mercury and lead hydrosols have a similar effect, differing only in 

 the time curve. Large quantities of collargol also increase the uric 

 acid excretion. 



Temperature Curve. 



The injection of a few cubic centimeters of silver hydrosol causes 

 a rise of temperature of varying but usually brief duration (M. 

 ASCOLI and G. IZAR*); on the other hand, the unstabilized hydrosols 

 have no observable effect on temperature (BOURGOUGNON*). This 

 corresponds with the observations on autolysis described above. 



Distribution. 



Finally, we must inquire, what becomes of the injected silver 

 hydrosol. This has already been investigated, at least as far as con- 

 cerns collargol injected intravenously. G. PATIN and L. ROBLIN * 

 found it chiefly in the liver but to a less extent in the kidney. They 

 contend that there occurs a concentration and gradual excretion 

 through the kidneys. S. BONDI and A. NEUMANN showed that col- 

 largol as well as other indifferent suspensions (india ink, fat) dis- 

 appear from the circulation within 1/2 to 1 hour after intravenous 

 injection and are temporarily deposited in the liver, bone marrow 

 and spleen. It is the star cells of VON KUPFFER which chiefly take up 

 these suspensions. 



J. VOIGT contributed especially accurate researches. He traced 

 the fate of the stored silver in the more important organs by examin- 

 ing microscopic sections in the ultramicroscope. Of his findings let 

 us emphasize particularly that it made a difference in the distribution 

 of the silver in the individual organs whether the animal was over- 

 whelmed by a single large quantity of silver solution or smaller 

 repeated doses were injected. There were definite differences in the 

 pictures obtained with different colloidal metals and metallic com- 

 pounds. According to personal, hitherto unpublished communica- 



