INFECTIONS OF THE DIGESTIVE TRACT 251 



cent, solution of the potassium cyanide. The doses 

 given sufficed to cause vomiting and some muscular 

 weakness, but no convulsions. The injections were 

 given during a period of two and one-half hours. At the 

 end of this 0.5 gm. of indol was injected subcutaneously 

 as in the first experiment. No further vomiting was 

 noted, but twitching of the muscles of the face and 

 legs was more marked than before. One and one-half 

 hours after the indol injections the animal was lively 

 and seemed to be recovering. Soon after he received 

 more cyanide, in consequence of which there developed 

 a few mild convulsions. There was much prostration 

 and dyspnoea and some fall in temperature. The odor 

 of indol was not detected at the fistulous opening. 

 Washings made from the gut were distilled and gave a 

 slight reaction for indol. It was found that the indican 

 reaction in the urine was delayed in its appearance as 

 compared with the previous experiment and that the 

 quantity of indican as judged by the intensity of the 

 color was considerably less developed in the Obermeyer 

 reaction. The quantity of indol excreted was thus 

 distinctly less than during the previous experiment. The 

 most striking feature of this experiment is the fact that 

 on the day following the administration of indol and 

 potassium cyanide the animal remained all day in a 

 condition of stupor interrupted by periods of frantic 

 and poorly coordinated movements in which he recog- 

 nized none of the attendants and did not respond to 

 calls. These seizures could be brought about by local 

 stimuli and resembled the behavior seen in dogs etherized 



