Cannon and Rosanofp : Heredity op Insanity 7 



The first combination, RR X RR oo RR, is represented in our 

 pedigree charts by three matings with a total of i6 offspring. 

 Theoretically all the offspring of such matings should be neuro- 

 pathic. The charts show that lo were neuropathic, 5 died in 

 childhood, and data concerning the remaining one are wanting. 



The second combination, DR X RR <» E)R + RR, is repre- 

 sented in our pedigree charts by nineteen matings with a total of 

 129 offspring. Theoretically one-half of these should be neuro- 

 pathic and one-half normal, but capable of transmitting the neuro- 

 pathic make-up to their progeny. The charts show: 45 neuro- 

 pathic, 14 normal with neuropathic offspring, 20 normal without 

 offspring, 27 normal with normal offspring, 20 died in childhood, 

 and concerning 3 data were unascertained. 



The third combination, DD X RR 00 DR, is represented in our 

 pedigree charts by five matings with a total of 18 offspring. 

 Theoretically all the offspring of such matings should be normal 

 but capable of transmitting the neuropathic make-up to their 

 progeny. The charts show : 8 normal with neuropathic offspring, 

 7 normal with normal offspring, 2 normal without offspring, and 

 I died in childhood. 



The fourth combination, DR X DR 00 DD -f 2DR -f RR, is 

 represented in our pedigree charts by seven matings, with a total 

 of 54 offspring. Theoretically one-fourth of these should be neu- 

 ropathic, one-half normal but capable of transmitting the neuro- 

 pathic make-up to their progeny, and the remaining one-fourth 

 normal and not capable of transmitting the neuropathic make-up 

 to their progeny. Our charts show: 12 neuropathic, 6 normal 

 with neuropathic offspring, 10 normal with normal offspring, 18 

 normal without offspring, and 8 died in childhood. 



The fifth combination, DD X DR 00 DD + DR, is represented 

 in our pedigree charts by only one mating, with 4 offspring. 

 Theoretically all the offspring should be normal, half of them 

 should and half should not be capable of transmitting the neuro- 

 pathic make-up to their progeny. The chart shows that all were 

 normal, one had neuropathic offspring, the rest had normal 

 offspring. 



The sixth combination, DD X DD x DD, is not represented in 

 our charts. This combination constitutes the mating of normal 

 individuals of pure normal ancestry, and should produce only 

 normal offspring. Since we have investigated the pedigrees of 



