568 



INDEX 



Anaphylaxis. quantitative 

 methods applied 

 to study of, 389 



Ranzi's work on, 367 



relation of alexin to, 

 391 



relation of antibodies 

 of, to other anti- 

 bodies, 401 



Richet and Hericourt's 

 work on, 360 



Richet and Portier's 

 work on, 360 



Rosenau and Anderson's 

 work on, 362, 376 

 et seq. 



sessile receptors, theory 

 of, 399 



specificity of, 362, 363 



sympathetic ophthalmia 

 and, 439 



Theobald Smith phenom- 

 enon in, 361 



Theobald Smith's work 

 on, 363 



toxic action of normal 

 sera and, 406 



toxin hypersusceptibility 

 and. 409 



transference of, 362, 380 

 et seq. 



true antigen-antibody re- 

 action, 388 



tuberculin ophthalmo-re- 

 action and, 442 



tuberculin reaction and, 

 440. See also Tu- 

 berculin reaction 



tuberculin skin reaction 

 and, 442 



Vaughan and Wheeler's 

 theory of mecha- 

 nism 'of, 390 



Vaughan and Wheeler's 

 work on toxic 

 fraction of pro- 

 tein molecule in, 

 . 390 



Vaughan's work on, 366, 

 367 



Weichhardt and Schit- 

 tenhelm's work 

 on. 369. 370 



with bacterial extracts, 

 363 



with normal serum, 362 



with proteins, 362 

 Anaphylaxis. bacterial. 412 



anaphylatoxin formation 

 in, 414. See also 

 under Anaphyla- 

 toxin 



endotoxin theory of pro- 

 duction of. 414 



Friedberger's e x p e r i - 

 ments in, 415, 

 416, 417 

 facts deduced from, 



417 



effect of excess of 

 bacteria adminis- 

 tered in, 418 

 effect of excess of 

 sensitization on 

 anaphylatoxin in, 

 418 



effect of too pro- 

 longed exposure 

 in anaphylatoxin 

 in, 418 



nature of bacterial in- 

 fections and, 420 

 et seq. 



Anaphylaxis, bacterial, 



N e u f e 1 d and 



Dold's e x p e r i - 



ments in, 419 



serum anaphylaxis and, 



413 



Vaughan's theory of bac- 

 terial spitting as 

 cause of. 414, 415 

 Anaphylaxis, passive, 380 



et seq. 

 Doerr and Russ's work 



on, 381 



duration of, 382 

 Friedemann's work on, 



380. 381, 382 

 Gay and Southard's 

 work on, 380. 381 

 interval between injec- 

 tion of sensitized 

 serum and injec- 

 tion of antigen in, 

 382, 383 



methods of production 

 of, 380, 381, 382 

 nature of reaction of. 382 

 Nicolle's work on, 380 

 Otto's work on, 380 

 Richet's work on. 380 

 Weill-Halie and Le- 

 maire's work on, 

 383 



Anderson and Schultz's 

 work on anaphy- 

 laxis, 365 

 "Anergie," 509 

 Anthrax, relative suscepti- 

 bility of man and 

 animals to, 53 

 study of, in regard to 

 resistance and 

 immunity. 296 

 vaccination against, his- 

 tory of. 64 

 method of. 64 

 Anthrax bacilli, attenua- 

 tion of virulence 

 of, 18 



virulence of. 15 

 Anti-alexin. 157 

 action of. 157 

 Anti-amboceptor, 152, 153 

 Anti-anaphylaxis, 362, 377 

 Besredka's work on, 375 



et seq. 



mechanism of. 402 et seq. 



desensitization in, 403 



tolerance to anaphy- 



lactic poison in, 



403 



methods of producing, 



377-378 



Besredka and Stein- 

 hardt's methods, 

 377 



Rosenau and Ander- 

 son's methods. 378 

 specificity of, 379. 404 

 "Anti-antibodies." 147 

 Antibodies. concentration 

 of. in lymphatic 

 organs in active 

 immunity. 101 

 in other organs in ac- 

 tive immuniza- 

 tion. 102 

 in active immunization, 



85 



locality of production 

 of, dependent on 

 locality of anti- 

 gen concentra- 

 tion, 102 



Antibodies, normal, expla- 

 nation of, 234 

 origin of, 100 

 specificity of, 85 

 Antibody formation, body 



cell in, 125 

 chemical nature of. 



126 



chemical action of anti- 

 gens in, 128 



in active immunity, re- 

 moval of spleen 

 and, 101 



mechanism of (side 

 chain theory), 124 

 by internal secretion 

 of body cell, 125 

 processes of metabol- 

 ism and, 125 

 overproduction of recep- 

 tors in, 128 

 principles of, 94. 96 

 Anticomplement, 157 



action of, 157 

 Anticytophile interpreta- 

 tion of anti-sensi- 

 tization (Ehrlich 

 and Morgenroth), 

 153 



controversy on, 153 

 "Antiformin." 70 

 Antigen-antibody reactions, 

 129. See also 

 Toxin - antitoxin 

 reaction 



antibody production in 

 body cells in, 130 

 relationship between 

 susceptibility of 

 tissue and toxin- 

 binding properties 

 in, 131 

 side chain theory in, 



129 



specificity of, 98, 129 

 variety of antibodies in, 



129 



agglutinins, 129 

 antitoxins, 129 

 cytotoxins, 129 

 precipitins, 129 

 Antigenic properties of 

 cells, relation of, 

 to lipoid constit- 

 uents, 97 



Antigens, action of, 95 

 active immunization 

 with, analogies to 

 drug tolerance, 

 99 



characteristics of. vari- 

 ations in, 98, 99 

 classification of. 95 

 complex structure of. 

 Ehrlich and Mor- 

 genroth's concep- 

 tion of. 151 

 Definition of. 35. 94 

 "local" immunity in or- 

 gans directly in 

 contact with, 

 102 



locality of production of 

 antibodies depen- 

 dent on locality 

 of concentration 

 of. 102 



organ specificity of, 99 

 protein nature of, 97 

 specificity of, 98 

 Anti-isolysins. 147 

 , "Antiricin." 85 

 ! Antisensibilisin, 386 



