INDEX 



569 



Antisensitization. a n t i - 

 cytophile interpre- 

 tation of (Ehrlich 

 and Morgenroth ), 

 153 



controversy on. 153 

 Antisensitizers. 152, 153 

 non-specificity of, 154 

 Antitoxic serum, direct ef- 

 fect of, on toxin, 

 104 



indirect protective ac- 

 tion of. against 

 toxin, 104 

 "normal" serum of Behr- 



ing, 107 



Antitoxin, chemical rela- 

 tions of. with 

 toxin, 114 

 definition of, 85, 86 

 diphtheria. See Diph- 

 theria antitoxin 

 production of. 129 



by true toxins, 35 

 snake venom, 466 



effect of heat on, 105 

 specific, substances in- 

 citing, 86 



standardization of, 465 

 by means of toxin, 



107 

 guinea pigs used in, 



108 

 tetanus, production of, 



4G5 



use of. in passive im- 

 munization. 86 

 Antitoxin unit, diphtheria, 



107 



Antitoxinogen, 95 

 Antivenin, 466 

 Arrhenius and Madsen on 

 neutralization in 

 t o x i n-antitoxin 

 reaction, 120 

 Arthus, phenomenon of, 



380 

 work of. on anaphylaxis, 



361 



Ascoli and Izar's work on 

 meiostagmin reac- 

 tion. 538, 539 

 Asiatic cholera, relative 

 susceptibility of 

 man and animals 

 to. 53 

 Asthma, anaphylaxis and, 



436 



Atrepsie. 56 

 Attenuation of bacteria by 



chemicals, 66 

 by cultivation under 



pressure, 66 

 by drying, 65 

 by heating. 65 

 by passage through ani- 

 mals. 65 



by prolonged cultivation 

 above optimum 

 temperature. 65 

 by prolonged growth on 

 artificial media in 

 presence of own 

 metabolic prod- 

 ucts. 65 

 capsule formation in, 



18 



Auer and Lewis's work on 

 anaphylaxis, 364 

 Autocytotoxins, 93 

 Autogenous vaccines, 351 

 "Autohemolvsins," 146, 

 147 



Auto-inoculation by mas- 

 sage in active 

 immunization, 340 



Autolysins, 146 



Autosensitization in ana- 

 .phylaxis, 373 



Auxilysin, 167 



Avian tuberculosis, relative 

 susceptibility of 

 animals to, 52 



Bacillus botulinus, action 



of, 4 



Bacteria, adaptation of, in 

 body, 6, 7 



agglutinability of, alter- 

 ations in, 226 

 by cultivation in im- 

 mune serum, 228 

 caused by heating, 



226 



normal differences 

 in, between 

 strains of same 

 species, 228. 229 

 spontaneous, 227 

 in agglutinoid, 229 



agglutination in. See 

 under Agglutina- 

 tion 



"agglutinin" bacteria, 

 agglutination of, 

 243 



aggressin secretion of, 

 in body, and vir- 

 ulence of, 20-22 



anti-opsonic properties 

 of, and antichem- 

 o t a c t i c sub- 

 stances, 325 



artificial cultivation of, 

 10 



attenuation of, 18 



methods of, 65. See 

 also under Atten- 

 uation 



by laboratory ma- 

 nipulations. 17 



capsulated. agglutination 



of, 243 

 virulence of, 326 



capsule formation in, 

 and virulence, 18 



colloid phenomena and 

 action in, 560 



destruction of. by cy- 

 tases in leuko- 

 cytes, 301. 302 

 by exudates. 300 

 by phagocytes, 300 



different strains of. va- 

 riation in infec- 

 tion from. 15. 16 



ectoplasmic hypertrophy 

 of. in relation to 

 virulence, 19, 20 



effect of body tempera- 

 ture on invasive 

 powers of. 12 



effect of cultural adap- 

 tation of. on vir- 

 ulence. 12 



effect of path of intro- 

 duction of. on 

 infection, 12-14 

 on virulence of. 12-14 



effect of quantity of, in- 

 troduced, on in- 

 fection. 14 



entrance of. into body 

 tissues, 6 



generalized action of, 24 



; to phagocy- 

 of, 325 



Bacteria, growth of, within 

 leukocytes, 298 



in blood stream, 24 



in localized infection, re- 

 action to, 26 

 through accidental 

 conditions, 25 



in normal serum, resis- 

 tance 

 tosis 



incubation of, 26 



localized action 

 of, 23 



measurement of relative 

 degrees of viru- 

 lence of, 15 



negative charge of, in 

 suspension, 242 



number of, introduced, 

 and relative viru- 

 lence, 15 



occurrence of, 2 



parasitic and saprophy- 

 tic, classification 

 of, 11 



phagocytosis of. See 

 under Phagocyto- 

 sis 



relative vi.-ulence of dif- 

 ferent strains of 

 same, 15, 16 



resistance of, to phago- 

 cytosis, due to 

 nonabsorption of 

 opsonin, 326 



resistance of living cell 

 to, 6 



secondary abscesses 

 caused by, 25 



selective action of, in 

 localized infec- 

 tion, 25 



selective lodgment of, in 

 tissues, 40 



sensitized, immunization 

 with, 68 



sensitized and unsensi- 

 tized, influence of 

 salts on aggluti- 

 nation of, 243, 

 244 



similar conditions pro- 

 duced by differ- 

 ent, 23 



specificity of. and infec- 

 tion, 22 



toxicity of, 423 



use of, in active immu- 

 nization, 85, 87- 

 89 



variation in virulence of, 

 when successively 

 passed through 

 animals. 16, 17 

 Bacterial anaphylaxis. See 

 Anaphylaxis, bac- 

 terial 



Bacterial extracts, active 

 i m m u n i z ation 

 with. 69 



extraction of bacteria 

 for. by mechan- 

 ical methods. 71 

 by permitting them 

 to remain in fluid 

 media. 70 



Bacterial infections, con- 

 ceived as reac- 

 tion of body 

 against a foreign 

 antigen, 421 



Bacterial precipitins, group 

 reactions in, 251 



