578 



INDEX 



Opsonins, definition of, 313 

 immune, bactericidal 

 sensitizers and, 

 321 et seq. 

 increase of, 315 



heated, increase of 

 power of, by ad- 

 dition of fresh 

 normal serum, 318 

 reactivation of, by 

 addition of alex- 

 in, 318 

 normal and, 320 et 



scq. 

 resistance of, to heat, 



315 



specificity of, 321 

 thermostability of, 320 

 normal, 91 



cooperation of heat- 

 stable and heat- 

 sensitive body in, 

 319 



instability of, 314, 315 

 nature of, 316 

 similarity of, to alex- 

 in or complement, 

 316, 317 



specificity of, 318 

 production of, in thyroid 



gland, 173 



qualitative difference be- 

 tween normal and 

 immune, 315, 

 316 



specific thermostable, in 

 normal serum. 

 317 



Organ specificity of anti- 

 gens, 99 



"Osmotic theory" of im- 

 munity, 84 

 Otto's work on anaphy- 



laxis. 361 

 in passive anaphylaxis, 



380 



Oxidase, in proteolytic en- 

 zymes, 527 



Pancreas cytotoxin, 92 



Panum's theory of intra- 

 cellular destruc- 

 tion of bacteria 

 in natural immu- 

 nity, 78 



Parasites, biological transi- 

 tion of sapro- 

 phytes to. 5 



Bail's classification of, 

 11 



Parasitic bacteria, 4 



Paratyphoid fever, agglu- 

 tination reaction 

 in diagnosis of, 

 221 

 immunization against, 



484 

 vaccination against. 484 



Paroxysmal hemoglobin- 



uria. 147 

 hemolysis in, 147 



Partial absorption method 

 of E h r 1 i c h in 

 measurement of 

 toxin -, antitoxin 

 combination, 115 



Pasteur, "exhaustion the- 

 ory of," 83 



experimentation of, on 

 i m m u n ization 

 against chicken 

 cholera, 63 



Pasteur, work of, on immu- 

 nization against 

 anthrax, 64 

 on prophylactive im- 

 munization in ra- 

 bies, 492 



Pathogenic bacteria, adap- 

 tation of, in tis- 

 sues, 6, 7 



entrance of, in body tis- 

 sues, 6 

 saprophytic nature of 



certain, 4 



Pathogenic micro-organ- 

 isms, definition 

 of, 3 



occurrence of, 2 

 resistance of living cell 



to, 6 



Pearce and Eisenbrey's 

 work on anaphy- 

 laxis, 368, 369 

 Persensitized cells, 180 

 Petterson's investigations 

 on therapeutic use 

 of leukocyte ex- 

 tracts, 308 



Pfaundler's thread reac- 

 tion in agglutina- 

 tion, 222, 223 

 Pfeiffer on causes of bac- 

 terial anaphylax- 

 is, 414 

 work of. on anaphylaxis. 



366 



"Pfeiffer phenomenon" in 

 active immuniza- 

 tion, 89 



in bacteriolysis. tech- 

 nique of, 138 et 

 seq. 



Metchnikoff's view of 

 phagocytosis in 

 peritoneal exu- 

 date and, 302 

 Phagocytes, 276 

 fixed, 276 

 macrophages, 277 

 microphages, 277 

 motile, 276 

 Phagocytic index. 331 

 Phagocytosis, 272 



acquired immunity and. 



298 



a 1 e x i n extraction in. 

 from leukocytes 

 and lymphatic or- 

 g a n s , 304 et 

 seq. 

 chemotaxis in. 285 



influence of bacteria 



in. 288. 289 

 influence of bacterial 



extracts in. 288 

 malic acid in, 286 

 of slime-molds or myx- 



omycetes, 286 

 of spermatozoa of 



ferns, 286 

 Pfeffer's technique in. 



286 

 destruction of bacteria 



in. 297, 300 

 by alexin (or cytasr) 

 in leukocytes, 



301. 302 

 action of, 302 

 Metchnikoff's inter- 

 pretation of, 302 

 by exudates. 300 

 by phagocytes, 300 

 destruction of red blood 

 cells by, 276 



Phagocytosis, differences in 

 degree of. due to 

 bacteria, 325 

 differences in phagocytic 

 energy in, due to 

 leukocytes in, 324 

 differences in virulence 

 of bacteria, de- 

 pendent on their 

 resistance to leu- 

 kocytes in, 325 

 digestion among proto- 

 zoa and, 274 

 "dust cells" in, 279 

 early investigations in. 



272 

 endothelial cells in, 278. 



279 



enzj'mes in, endocellular 

 and extracellular. 

 305 



eosinophile cells in, 27<s 

 factors determining, 311 

 tixateur or sensitizer in. 

 action of, in im- 

 munized animals. 

 301 



giant cells in, 280 

 foreign body. 280 

 tuberculous, 280 

 in daphnia, 296 

 in higher animals, 296 

 in immune serum, 315 

 bacteriolysins in, bac- 

 tericidal sensitiz- 

 ers and, 321 ft 

 neq. 



heated, opsonic action 



in, increase of, by 



addition of fresh 



normal serum, 31. S 



increase of. 311 



attributed to "stim- 



ulins," 311 

 with addition of 



leukocytes, 312 

 opsonin contents a 



factor in, 313 

 opsonins in, increase 



of, 315 

 normal opsonius 



and. 320 et seq. 

 specificity of, 321 

 thermostability of, 



320 



in immunity, 90 

 in normal serum, op- 

 sonins in, cooper- 

 ation of h e a t- 

 sensitive body in, 

 319 



nature of, 316 

 similarity of, to 



alexin, 316, 317 

 specific thermosta- 

 ble. 317 



specificity of, 318 

 in process of inflamma- 

 tion, 280 et seq. 

 with pyogenic staphy- 



lococci. 281 

 with tubercle bacilli, 



283 



increase of. by injection 

 of leukocyte ex- 

 tracts, .308 et seq. 

 in increased resis- 

 tance, 329 

 with acquisition of 



immunity, 299 

 intracellular digestion 



and, 274 

 in vertebrates, 275 



